Epigenetic effects of glucose and pheromones on the methylome

Science 9 August 2013:
Vol. 341 no. 6146 pp. 626-627

The Maturing Brain Methylome

Harrison W. Gabel, Michael E. Greenberg

Excerpt: “The authors chart out striking postnatal alterations in neuronal methylation profiles that occur as synapses develop and are refined, from the fetal to adult stage. The patterns suggest that DNA methylation is important in the maturation of neurons in the developing brain.”

My comment: I presented a poster today at the ISHE Summer Institute with the title: ‘Nutrient-dependent / pheromone-controlled adaptive evolution’ and subtitle: a mammalian model of thermodynamics and organism-level thermoregulation. I included examples of nutrient-dependent ecological niche construction and pheromone-controlled social niche construction that lead to neurogenic niche construction (e.g., in nematodes) and to socio-cognitive niche construction in invertebrates (e.g., the honeybee) and vertebrates including mammals.

A mouse model of a single amino acid substitution with effects on observable phenotypic traits that enable selection for reproductive fitness, links epigenetic effects of nutrient uptake during the past ~30,000 years to selection for socio-cognitive niche construction in the human brain via the conserved molecular mechanisms across species that enable adaptive evolution of the brain and behavior via pheromone-controlled reproduction.

In accord with Lister et al., it appears that the epigenetic effects of glucose and of pheromones on the gonadotropin releasing hormone (GnRH) neuronal system, allow the pulses of GnRH to integrate information provided by complex feedback mechanisms that alter the GnRH pulse and everything downstream from GnRH secretion throughout the life of all vertebrates (sans mutations). Thus, adaptive evolution is nutrient-dependent and pheromone-controlled across all species and mutations can now be looked at more clearly in the context of disease, not mutation-driven evolution.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society