Epigenetic effects of environmental perturbations

A hidden genetic code Sunday, Jan. 20, 2013 Harvard Gazette

Researchers identify key differences in seemingly synonymous parts of the structure

Excerpt: “Given the universal nature of the genetic code — the system works the same way for all organisms, from single-celled bacteria to human beings — Subramaniam hopes to explore what role, if any, differences in the seemingly synonymous portions of the genetic code may have in other organisms, and whether those differences can be exploited by researchers.”

Open access article: Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria

My comment:

A hidden genetic code altered only by nutrients could not lead to beneficial adaptations via mutations, which are typically deleterious. Instead, species diversification in microbes to man is controlled by the metabolism of nutrients to pheromones — not by mutations. Nutrient-dependent pheromone-controlled reproduction is not a function of mutations; it’s a function of life that begets other life and the observed diversity of life that is nutrient dependent and pheromone-controlled.

The epigenetic effects of nutrient chemical stress and social stress alter the microRNA/messenger RNA balance, intracellular signaling, and stochastic gene expression that is responsible for adaptive evolution in species from microbes to man.  That’s how chemical ecology is linked to the cellular metabolism of nutrients that chemically control reproduction.  As indicated by Subramaniam, the systems biology approach is the same in all organisms.

The receptor-mediated molecular handshake that enables E. coli to metabolize citrate exemplifies how the epigenetic landscape becomes the physical landscape via chromatin remodeling. Nutrient-dependent pheromone-controlled reproduction of E. coli via quorum sensing ensures that the organism does not exhaust its nutrient supply.

In this article, however, nutrient-dependent perturbations are inappropriately placed in the context of mutating codons.  Perturbations cause mutations that lead to an evolutionary dead end. Indeed, the researchers note that mRNA cannot solely be responsible for adaptive evolution of de novo gene expression and protein synthesis. There must be top-down control of nutrient-dependent perturbations, and that control comes from the metabolism of nutrients to pheromones.

Perturbations in the balance enable stochastic gene expression that is controlled by the epigenetic effects of the metabolism of nutrients to species specific pheromones. The pheromones control nutrient-dependent reproduction via alterations in the  microRNA / mRNA balance.


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society