Epigenetic control of female puberty and sexual orientation

In case you missed it…
Can Epigenetics Explain Homosexuality?

By Sabrina Richards

Scientists propose a new model for how homosexuality develops, but observers say it will be difficult to test.


My comment: I attempted to add the comment below, but am not sure it will be posted to the Scientist site.

In my model, the epigenetic control of female puberty also links nutrient-dependent pheromone-controlled adaptive evolution in microbes to control of sex differences in GnRH-directed brain development and behavior in mammals. In the context of pre-pubertal GnRH-directed mammalian brain development and behavior, I tried to emphasize earlier that sex-specific regulation of miRNA levels are known to influence sexually dimorphism of mRNA.  Now, there’s evidence that the Polycomb group (PcG) of transcriptional silencers (the PcG complex) represses sexual maturity “…by targeting downstream genes involved in the stimulatory control of GnRH secretion at puberty.”

That evidence takes me back to a section on molecular epigenetics in our 1996 review “From fertilization to adult sexual behavior” (with my emphasis, sans citations): “Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes. Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans. That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.”

Translation: Sex differences in behavior and sexual orientation are determined genetic predispositions and by nutrient chemicals and pheromones that epigenetically effect the microRNA / messenger RNA balance, intracellular signaling, and stochastic gene expression during the GnRH-driven prenatal and postnatal maturation of the brain and behavior in heterosexuals and homosexuals. While this explanation of sexual orientation is not as simple as other attempts to explain away sexual orientation, the details of how genetically predisposed differences in sexual orientation are epigenetically effected also explain the diversity of sexual behaviors observed across species and in our own.

Simply put, the molecular biology of nutrient-dependent pheromone-controlled adaptive evolution is the same in species from microbes to man. That makes the “answer to homosexuality” the same as the answer for other  causality.  The cause is genetically predisposed nutrient-dependent pheromone-controlled adaptive evolution. How could it not be?

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society