Epigenetic and physical landscapes linked again?

We linked the epigenetic and physical landscapes in our 1996 Hormones and Behavior review. They have since been linked at least twice via the de novo Creation of olfactory receptor genes.

Nuclear compartmentalization of odorant receptor genes (2014)

Excerpt: “Significance

The mechanisms underlying odorant receptor (OR) monoallelic and monogenic expression are unclear. We show for the first time that the nuclei of olfactory neurons have a characteristic organization of facultative heterochromatin: it is highly concentrated around a large constitutive heterochromatin block located centrally in the nucleus.”

My comment: This appears to be another report that links the epigenetic landscape and physical landscape of DNA via the de novo creation of olfactory receptor genes.

See also: Smell of Genes Packed Away and my blog post from December 20, 2013 Biophysical evidence of Creation via adaptations: The holy grail of evolutionary biology?

Excerpt:  How keeping active pays off in the olfactory system

On 12/17/2012, I asked: Is what’s being elucidated the bottom-up epigenetic effects on stochastic gene expression via chromatin remodeling, which is controlled by the top-down epigenetic effects of pheromones on reproduction in species from microbes to man?

Also, in our 1996 review, TB addressed the location of heterochromatin in the nucleus in the context of sex differences linked from genes on sex chromosomes to hormones and behavior.


‘The Genome, positioning, timings. There are major structural differences between the X and Y chromosomes; e.g., centromeric aiphoid repeats sequences and distribution of heterochromatin (Graves, 1995; Wolfe et al., 1985). These structural differences correlate with sexually dimorphic chromosomal positioning within the nucleus and with male/female differences in replication timing of the active X, the inactive X, and the Y chromosomes, e.g., Boggs and Chinault (1994), Clemson and Lawrence (1996); Hansen, Canfield, and Gartler (1995). Increasingly the structure and timings within the nucleus are realized as contributing to gene expression regulation (Manders, Stap, Strackee, van Driel, and Aten, 1996; Stein, Stein, Lian, van Wijnen, and Montecino, 1996).”

What I’ve continued to see is experimental evidence that the nutrient-dependent pheromone-controlled alternative splicing of pre-mRNA establishes an epigenetic continuum of biologically based cause and effect in species from microbes to man via amino acid substitutions and chromosomal rearrangements. What I have not seen is any evidence that others are even vaguely aware of how my model has developed since 1996 .

Either my published works are being ignored, or others would rather continue reporting their “firsts,” which are appearing more than 16 years later. Alternatively, I could be wrong about the most obvious link between the epigenetic landscape and the physical landscape of DNA.  If so, no one has told me why I’m wrong. Many have told me that mutation-initiated natural selection causes speciation, but they have not provided experimental evidence to support what many others have been saying about mutation-driven evolution for several decades.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society