Excerpt 1) “…the theory neglects key processes, say Kevin Laland and colleagues.”
My comment: “Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans (Keller et al., 2007; Kohl, 2007; Villarreal, 2009; Vosshall, Wong, & Axel, 2000).” — Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. (2012)
Excerpt 2) “Theory accommodates evidence through relentless synthesis…”
My comment: “An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.” Nutrient-dependent/pheromone-controlled adaptive evolution: a model.(2013)
Evolutionary theory represents the failure to accommodate all existing evidence of biophysically-constrained biologically plausible effects on genes and affects on behavior that link the epigenetic landscape to the physical landscaped of DNA via conserved molecular mechanisms in species from microbes to man.
Serious scientists have never accepted claims that RNA-directed DNA methylation and the RNA-mediated events that link ecological variation to ecological adaptations via nutrient-dependent amino acids substituitions occur randomly. The idea that random mutations, instead of amino acid substitutions, could lead to increasing organismal complexity is ridiculous.
Serious scientists have detailed many aspects of epigenetically effected gene, cell, tissue, organ, organ system pathway. Pseudoscientis who continue to tout their theories about how species evolved have yet to provide even on example of an evolutionary event for comparison to across species examples of nutrient-dependent RNA-mediated events that are controlled by the metabolism of nutrients to species-specific pheromones in all genera.
Psudoscientists would rather continue to believe that Lenski’s E. coli and Desai’s yeasts mutated when it is obvious that they ecologically adapted to variation in the supply of nutrients, which is what every cell of every individual of every species must do if they are contribute to the gene pool of subsequent generations of species from microbes to man via an atoms to ecosystems model of epigenetic cause and effect.
“Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism [of RNA-mediated events], contribute to sexual differentiation in at least two species…”
No other mechanism has been described that links atoms to ecosystems.
“This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.”