Ecological factors excluded from mutation-driven evolution

Intelligent Mitochondria Communication with Neurons

by Jon Lieff, Jan 25, 2014

Excerpt: “Mitochondria respond instantly to mental processes and provide the energy that drives the neuron. While spawned near the cell body, mitochondria travel throughout the entire cell, including axons that can be two feet long, to provide energy at synapses. The neuron needs them for energy, buffering of the critical calcium signals, the movement of vesicles providing material to the far-reaching areas of the neuron, energy for transmission of neurotransmitters, scaffolding, neuroplasticity, the electrical spike along the axon, and the metabolism that builds proteins, lipids and steroids.”

My comment: The human influenza virus uses glucose to support its replication and the diversification of its antigenic properties via amino acid substitutions. The amino acid substitutions enhance thermodynamic stability but perturb glucose-dependent cognitive thermodynamics in infected individuals.

Incorrectly attributing the antigenic changes in the human influenza virus to mutations is leading us to a crisis. This medical crisis is brought upon us by those who continue to believe in mutation-initiated natural selection after all experimental evidence has shown that ecological variation, such as variation in the availability of glucose, is the cause of adaptations — even in viruses, which have no mitochondria.

The availability of glucose is the limiting factor in adaptations of the human influenza virus. These adaptations currently are causing alarm in populations where the virus has adapted and people of all ages are dying. The escalating problem can be traced to the experimentally unsupported theory of mutation-driven evolution in viruses.

No experimental evidence of mutation-initiated natural selection has been found in any living organism. We may need something akin to the Scopes trial to alleviate human suffering. Perhaps the racist claims associated with mutation-driven evolution may again be the driving force for change.

The atoms to ecosystems approach to ecological adaptations eliminates the racist claims of evolutionary theorists by integrating what is known about diet and systems biology.  For instance, the role of calcium signals is critical in interactions at the atomic level, which links physics and chemistry to the conserved molecular mechanisms of ecological adaptations in brain tissue. This extends ecological adaptations in other mammals to differences in heart muscle tissue of human subjects whose diet predicts cardiovascular morbidity and mortality.

See for example, Kohl (2013) From ion channel to organismic phenotype: An example of integrative translational research into cardiac electromechanics. “This illustrates the utility of studying biologic behavior across multiple levels of structural and functional complexity.” For comparison, belief in mutation-initiated natural selection led to racist beliefs about the role that mutations must play in differences in death rates from cardiovascular disease. See for example, Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations.

There is no mention of mutations in the article text, but the following except shows how the study results were reported in terms of an experimentally unsubstantiated theory.

Excerpt:The next phase of the study involving the newly discovered gene mutations will investigate their function, using human blood samples at the molecular level.

Those who continue to tout mutation-driven evolution in the context of racial differences take us back to the time of the 1925 Scopes trial and the racist comments in the book that led to the trial.

A Civic Biology: Presented in Problems (New York, 1914):

pp. 195-196 “Evolution of Man. – Undoubtedly there once lived upon the earth races of men who were much lower in their mental organization than the present inhabitants. If we follow the early history of man upon the earth, we find that at first he must have been little better than one of the lower animals. He was a nomad, wandering from place to place, feeding upon whatever living things he could kill with his hands. Gradually he must have learned to use weapons, and thus kill his prey, first using rough stone implements for this purpose. As man became more civilized, implements of bronze and of iron were used. About this time the subjugation and domestication of animals began to take place. Man then began to cultivate the fields, and to have a fixed place of abode other than a cave. The beginnings of civilization were long ago, but even to-day the earth is not entirely civilized.

The Races of Man. – At the present time there exist upon the earth five races or varieties of man, each very different from the other in instincts, social customs, and, to an extent, in structure. These are the Ethiopian or negro type, originating in Africa; the Malay or brown race, from the islands of the Pacific; the American Indian; the Mongolian or yellow race, including the natives of China, Japan, and the Eskimos; and finally, the highest race type of all, the Caucasians, represented by the civilized white inhabitants of Europe and America.”

pp. 253-254 ‘Charles Darwin and Natural Selection. – The great Englishman Charles Darwin was one of the first scientists to realize how this great force of heredity applied to the development or evolution of plants and animals. He knew that although animals and plants were like their ancestors, they also tended to vary. In nature, the variations which best fitted a plant or animal for life in its own environment were the ones which were handed down because those having variations which were not fitted for life in that particular environment would die. Thus nature seized upon favorable variations and after a time, as the descendants of each of these individuals also tended to vary, a new species of plant or animal, fitted for the place it had to live in, would be gradually evolved.”

“Artificial Selection. – Darwin reasoned that if nature seized upon favorable variants, then man by selecting the variants he wanted could form new varieties of plants or animals much more quickly than nature. And so to-day plant or animal breeders select the forms having the characters they wish to perpetuate and breed them together. This method used by plant and animal breeders is known as selection.”

p. 261 “Improvement of Man. – If the stock of domesticated animals can be improved, it is not unfair to ask if the health and vigor of the future generations of men and women on the earth might be improved by applying to them the laws of selection. This improvement of the future race has a number of factors in which as individuals may play a part. These are personal hygiene, selection of healthy mates, and the betterment of the environment.”

p. 261 “Eugenics. – When people marry there are certain things that the individual as well as the race should demand. The most important of these is freedom from germ diseases which might be handed down to the offspring. Tuberculosis, syphilis, that dread disease which cripples and kills hundreds of thousands of innocent children, epilepsy, and feeble-mindedness are handicaps which it is not only unfair but criminal to hand down to posterity. The science of being well born is called eugenics.”

pp. 261-262 “The Jukes. – Studies have been made on a number of different families in this country, in which mental and moral defects were present in one or both of the original parents. The “Jukes” family is a notorious example. The first mother is known as “Margaret, the mother of criminals.” In seventy-five years the progeny of the original generation has cost the state of New York over a million and a quarter dollars, besides giving over to the care of prisons and asylums considerably over a hundred feeble-minded, alcoholic, immoral, or criminal persons. Another case recently studied is the “Kallikak” family. This family has been traced back to the War of the Revolution, when a young soldier named Martin Kallikak seduced a feeble-minded girl. She had a feeble-minded son from whom there have been to the present time 480 descendants. Of these 33 were sexually immoral, 24 confirmed drunkards, 3 epileptics, and 143 feeble-minded. The man who started this terrible line of immorality and feeble-mindedness later married a normal Quaker girl. From this couple a line of 496 descendants have come, with no cases of feeble-mindedness. The evidence and the moral speak for themselves!

p. 263 “Parasitism and its Cost to Society. – Hundreds of families such as those described above exist to-day, spreading disease, immorality, and crime to all parts of this country. The cost to society of such families is very severe. Just as certain animals or plants become parasitic on other plants or animals, these families have become parasitic on society. They not only do harm to others by corrupting, stealing, or spreading disease, but they are actually protected and cared for by the state out of public money. Largely for them the poorhouse and the asylum exist. They take from society, but they give nothing in return. They are true parasites.”

The Remedy. – If such people were lower animals, we would probably kill them off to prevent them from spreading. Humanity will not allow this, but we do have the remedy of separating the sexes in asylums or other places and in various ways preventing intermarriage and the possibilities of perpetuating such a low and degenerate race. Remedies of this sort have been tried successfully in Europe and are now meeting with success in this country.”

p. 253: See the section on Mutations that might arise suddenly. Then see: Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

In Roles of Mutation and Selection in Speciation: From Hugo de Vries to the Modern Genomic Era ecological factors were removed from consideration “… to clarify the roles of mutation and selection…” When the nutrient-dependent pheromone-controlled de novo creation of genes in species from microbes to man is framed in the context of a ridiculous theory of mutation-driven evolution, it becomes harder to avoid making the same mistakes made by evolutionary theorists for more than 88 years. Changes in skin pigmentation and eye color can no longer be attributed to accumulated mutations across millions of years.

God help us all, if medical practitioners and researchers continue to make mistakes like they have in the past when they reported their results in terms of a ridiculous theory of mutation-driven evolution. Meanwhile, perhaps you can help by asking evolutionary theorists why they continue to exclude ecological factors from their explanations of mutation-driven evolution.

 

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society