DS Wilson’s view of biophysically constrained life (4)

Summary: Clearly, DS Wilson did not get Dobzhansky’s joke about Creation that began some 10 billion years ago in the context of an event that happened in 4004 B.C.

Others simply laughed and reported the joke in the context of Combating Evolution to Fight Disease

DS Wilson’s view of biophysically constrained life (3)

DS Wilson’s view of biophysically constrained life (2)

DS Wilson’s view of biophysically constrained life (1)

DS Wilson published a challenging misrepresentation of the facts about biophysically constrained life that directly conflicts with the facts from The : Mysteries of Odor in Human Sexuality (1995/2002) and everything else I have since published or presented. Simply put, all my claims have since been placed into the context of:  Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling via Energy as information and constrained endogenous RNA interference (video 2/15/17)

See for comparison: Science Salon #55 Dr. David Sloan Wilson—This View of Life: Completing the Darwinian Revolution.

David_S_Wilson & I discuss his new book, group selection, solving the is-ought/naturalistic fallacy, policy as a branch of biology, nationalism as religion.

Their discussion includes attacks on President Donald Trump at a time when he is gaining support from the majority of intelligent people in the USA. For comparison, here are my comments on the 1.5 hr interview, which was recorded in advance on 2/1/19. (As usual, I have provided links to support for my claims.)

Wilson has followed the ‘logic’ of Tinbergen for 17 years after publication of our 2001 award-winning review: Human pheromones: integrating neuroendocrinology and ethology (link opens pdf)

His epic failure to integrate the facts from neuroendocrinology to human ethology have left him unable to place anything he knows into the context of the food energy-dependent pheromone-controlled biophysical constraints on viral latency and the cure for cancer.

See: Accelerated Evolution Biotechnologies

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis).

My comments to Michael Shermer’s twitter feed:

If others who reject “Group Selection” will reject Tinbergen’s logic, there would be no reason to read “This View of Life.” DS Wilson thinks debate about the evolutionary origins of religion did not end with Ben Feringa’s presentation:

Re: The Resurrection of Christ. Who thinks it cannot be compared to the light-activated weekend resurrection of the bacterial flagellum?

Who is DS Wilson to question the facts presented in “What is Life” (1944) — without mention of the extant literature?

Dobzhansky (1973) claimed light was the link from food energy-dependent pheromone-controlled RNA-mediated amino acid substitutions in Dobzhansky (1964) to cell type differentiation in unicellular microbes and animals that vary in 56 to 72 amino acids.

Clearly, DS Wilson did not get Dobzhansky’s joke about Creation that began some 10 billion years ago in the context of an event that happened in 4004 B.C.
Others simply laughed and reported the joke in the context of Combating Evolution to Fight Disease

Did I really hear @michaelshermer mention spontaneous bottom-up self-organization and get complaints from DS Wilson about ‘selection’ at that level?

Ecology vs evolution: The nutrient-dependent pheromone-controlled change from C. elegans to P. pacificus, a predatory nematode with ‘teeth,’ is an adaptation that did not benefit other nematodes.

In the long view, DS Wilson cannot address cooperation among N Korea and scientific creationists in S. Korea that Trump facilitated.  “…if border restrictions are lifted, the viral infections, such as influenza, that are more common in South Korea…

I want to push back on this: Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7],
That is the theorist’s way to introduce a so-called “Sky Hook.”

Psychopathic insects and psychopathic chickens pit males against females without addressing facts about nutrient-dependent pheromone-controlled biophysically constrained viral latency and the prevention of school shootings via what’s known about COMT Val158Met.

Re: “Really good authors
I look forward to reading this since DS Wilson just linked all ecological adaptations from the ability to find food and the pheromone-controlled physiology of reproduction in primates to “emotion-driven” sympatric speciation.

To wrap this up, see: “Genetic, epigenetic and posttranscriptional mechanisms for treatment of… a paradigm–compulsive disorder

…altered levels of energy-dependent microRNA-mediated splice factors and posttranscriptional mechanisms regulate RNA stability

Thanks to Michael Shermer for helping David S. Wilson to make a fool of himself and others 17 years after the paradigm shift occurred via publication of: Human pheromones: integrating neuroendocrinology and ethology link opens pdf

See also:  Subjects’ plasma RNA was extracted and analyzed. This study determined that participants in the higher academic performance group had a significant difference in MECP2 mRNA expression compared to the lower academic performance group.

DS Wilson’s so-called “view of life” does not include anything that can be learned by ages 10+ via game play of:

Subatomic: An Atom-Building Board Game and Cytosis: A Cell Biology Board Game

Serious scientists can see for review: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

See for other examples of DS Wilson’s epic failure:

Homosexual Orientation in Males: Evolutionary and Ethological Aspects (2001)

The authors examine the combined effects of evolutionary factors and neurohormonal processes on the development of a homosexual orientation. It is suggested that research into the topic could benefi t from an examination of and change in some of the assumptions upon which much past research has been based.

Mating types in yeast, vomeronasal organ in rodents, homosexuality in humans: does a guiding thread exist? (2002)

Human body odour, genetic variability, and sexual orientation: a reply to D. Oliva. (2002)

Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind (2002) link opens pdf

Evolutionary psychologists often overlook a wealth of information existing between the proximate genotypic level and the ultimate phenotypic level. This commonly ignored level of biological organization is the ongoing activity of neurobiological systems.

The light-activated assembly of the microRNA-RNA-peptide nanocomplex has since been linked to the cure for all cancers via microRNA biogenesis in plants.

A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation

…plants alter microRNA (miRNA) biogenesis in response to light transition.

A microRNA biogenesis-like pathway for producing phased small interfering RNA from a long non-coding RNA in rice

Light Regulates Plant Alternative Splicing through the Control of Transcriptional Elongation

Why have microRNA biomarkers not been translated from bench to clinic?

See also: The light-dark regimen and cancer development (2002) link opens pdf

Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia (2015) link opens pdf

Overexpression of miR-21 and miR-122 in preeclamptic placentas (2015) link opens pdf

The apoptosis-associated miRNAs miR-21 and miR-122 are dysregulated in the term preeclamptic placentas. The increased miRNA expression suggest the downregulation of potential targets mRNAs, which can contribute to the pathogenesis of preeclampsia.

The Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression (2014)

Light-dark influence on enkephalinase activity in hypothalamus and pituitary (2018) link opens pdf

In standard light/dark conditions, the results demonstrated an opposite daily rhythm in hypothalamus and pituitary.

Photoperiod-induced neurotransmitter plasticity declines with aging: an epigenetic regulation? (2/27/19)

The overall increase in DNMT3a expression in SST+ cells of the PaVN may be attributable to polycomb loss since unmethylated regions bound by polycomb complexes have been shown to become methylated with aging (Jung and Pfeifer, 2015; Cedar and Bergman, 2012). This process would increase access to DNA and allow methylation levels to increase over time, resulting in a loss of plasticity.

We linked food energy pheromone-controlled polycombic ecological adaptations to biophysically constrained biodiversity in the molecular epigenetics section of this 1996 Hormones and Behavior review. From Fertilization to Adult Sexual Behavior

Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes (Saunders, Chue, Goebl, Craig, Clark, Powers, Eissenberg, Elgin, Rothfield, and Earnshaw, 1993; Singh, Miller, Pearce, Kothary, Burton, Paro, James, and Gaunt, 1991; Trofatter, Long, Murrell, Stotler, Gusella, and Buckler, 1995).

It is long past time for others to link the virus-driven hecatombic evolution of all pathology to the unnecessary suffering and premature death their ignorance has caused.

 

 

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society