Disorders of development: altered microRNA / messenger RNA balance

My recent poster presentation helps to explain the microRNA / messenger RNA balance in the context of adaptively evolved cell and organism homeostasis. For example, dietary or social stress can result in altered homeostasis, which results in physical and mental disorders. The biological complexity of the model is overwhelming but this 2-minute video representation on the importance of microRNA to physical disorders may prompt neuroscientists to examine my model and my published works in an attempt to learn more about how the altered microRNA / messenger RNA balance results in disorders of brain development and behavior.

From my poster: Main conclusion:

This model of systems biology (“biological embedding”) represents:

  • Nutrient chemical-dependent and social stress-induced intracellular changes in microRNA and messenger RNA homeostasis


  • Intermolecular changes in DNA


  • Experience-dependent stochastic variations in de novo gene expression for odor receptors


  • The required gene-cell-tissue-organ-organ system pathway that links sensory input directly to gene activation in GnRH neurosecretory cells of the mammalian brain


  • The required reciprocity that links gene expression to behavior that alters gene expression (i.e. from genes to behavior and back)

Next steps:

A model of how mutations might somehow cause adaptive evolution can now be compared to this model of nutrient chemical-dependent non-random adaptive evolution that is controlled by the epigenetic effects of pheromones on reproduction in species from microbes to man.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society