Diet, metabolism, pheromones and feedback

Nasal Sprays Offer Therapy with a Sniff

Nasal sprays may open the door for new medications

By Caitlin Shure

Excerpt: The secret to the nose’s potential lies in the nerve fibers embedded in its tissue. The nasal cavity houses the endings of nerves that connect to the brain stem and olfactory bulb. Chemicals traveling through or alongside these fibers can bypass the intimidating blood brain barrier. Consisting of tight cellular junctions, this barrier prevents most molecules in the bloodstream from reaching the brain. The barrier keeps pathogens out; however, it also limits the types of medications used to treat brain disorders. Intranasal delivery thus opens the door to entire new classes of therapeutic molecules—or even therapeutic cells.

My comment: The ketone body ²-hydroxybutyrate (²OHB) acts as an endogenous inhibitor of histone deacetylases (HDACs). That fact supports a model in which ²OHB  links diet to gene expression via chromatin modifications via metabolism to species-specific pheromones that epigenetically effect the physiology of reproduction. This is probably what happens with the production of the alcohol and ketone forms of different molecules linked to genetically predisposed differences in sexual orientation that are epigenetically-effected by olfactory/pheromonal input. For example, the metabolism of dehydroepiandrosterone (DHEA) and it sulfate DHEAS to its primary metabolites etiocholanolone and androsterone probably allow the most abundant steroid hormone found in humans to signal both reproductive fitness and sexual orientation to others via the androsterone:etiocholanolone ratio.

Margolese, M.S. (1970) Homosexuality: A new endocrine correlate. Hormones and Behavior, 1, 151‑155.
See also: Androsterone-etiocholanolone ratios in male homosexuals


About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society