Detailed mechanisms: The puzzle of what to do next?

Epigenetics: The sins of the father

The roots of inheritance may extend beyond the genome, but the mechanisms remain a puzzle by Virginia Hughes 05 March 2014

Excerpt: To many modern biologists, that’s “scary-sounding”, says Oliver Rando, a molecular biologist at the University of Massachusetts Medical School in Worcester, whose work suggests that such inheritance does indeed happen in animals3. If it is true, he says, “Why hasn’t this been obvious to all the brilliant researchers in the past hundred years of genetics?”.

My comment: Nearly all the brilliant researchers in the past hundreds of years of genetics have been taught to believe what population geneticists decided to believe. However, the population geneticists never learned about the basic principles of biology or the levels of biological organization required to link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man.

With no understanding of biology, and no experimental evidence to support their theories, population geneticists have since simply decided that mutation-initiated natural selection must be reduced to mutation-driven evolution. What choice do they have? No one ever showed what was naturally selected, or how genes were fixed in the populations of organisms that evolved. Now, they must believe that mutation-driven evolution “just happens.” It must, because statistical analyses say it happens … somehow.

Nothing else matters to a theorist but the math, as we’ve recently seen, especially when researchers wrote in 2011: “…we will not consider geographical and ecological factors because of space limitation. Our primary purpose is to clarify the roles of mutation and selection in the evolution of reproductive isolation…”    Anyone who is familiar with how Darwin’s theory was repeatedly inseminated with ideas from population genetics will recognize how fertilizing the minds of theorists led to the bastardization of Darwin’s theory and its bastard child: Mutation-Driven Evolution. All that is left of mutation-initiated natural selection is a theory of how constraint-breaking mutations somehow cause it.

Meanwhile, serious scientists have learned that The perceptual logic of smell links the nutrient-dependent pheromone-controlled de novo creation of olfactory receptor genes from their presence in unicellular spermatazoa to our experience-dependent receptor-mediated sense of smell via the conserved molecular mechanisms that link ecological variation to ecological adaptations in species from microbes to man. But don’t try to tell a theorist about biologically based cause and effect. They didn’t want to hear about detailed mechanisms before, and it’s too late now for them to learn about the requirement for experimental evidence. That requirement makes them look like fools who thought that the ecological, social, neurogenic, and socio-cognitive niche construction manifested in increasing organismal complexity “just happened.”

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society