Deletions, duplications, and other mutations

ScienceVol. 342 no. 6158 pp. 564-565 DOI: 10.1126/science.1246942
  • Perspective

Genetics

Our Fallen Genomes

Excerpt:  “…Darwin’s theory of evolution ultimately abetted a modern conceit—that the genomes in our cells are highly optimized end products of evolution.”

My comment: The ability to adapt to changes in the epigenetic ‘landscape’ is nutrient-dependent and pheromone-controlled in species from microbes to man.

Excerpt: “Deletions, duplications, and other mutations may arise at different places in a developmental lineage.”

My comment:  This perspective starts with the false premise that duplications (e.g., copy number variants) are mutations as if that misrepresentation was part of Darwin’s theory. Darwin knew nothing about genetics or epigenetics. Darwin’s theory did not cast duplications in the light of deletions or other mutations. Instead, Darwin repeatedly stated that ‘conditions of life’ were of primary concern before any consideration could be give to natural selection (e.g., for deletions or mutations).

Conditions of life are nutrient-dependent and so are copy number variants in yeasts (unicellular organisms).  In yeasts, nutrient-dependent pheromone-controlled reproduction is the mechanism through which one signaling pathway involved in nutrient uptake regulates a second pathway for pheromone-controlled reproduction. The regulation of pheromone production by nutrient uptake is how cells integrate different signals that enable them to produce a coordinated response.  The coordinated response ensures that the organized genomes of all cells in all extant organisms are the highly optimized end products of evolution.

In neurons of the human brain, copy number variants are determined by nutrient uptake and reproduction is controlled by pheromones. This means that neuronal copy number variants are controlled by nutrient-dependent production of pheromones via conserved molecular mechanisms of microbes to man.  Attempting to portray copy number variants as duplications that are like other mutations skews any other proper perspective that might have been provided by these authors.

It is simply not possible to start with a false premise, attribute it to Darwin, and then move forward to any sensible explanation of biologically based cause and effect. Instead, let’s start with the fact that: ‘One of the main duplicated gene families are the olfactory receptor proteins [18,117–119] so perhaps their duplication may lead to an increase in sensitivity to a particular odour may be adaptive under certain conditions.“That means the experience-dependent de novo creation of olfactory receptor genes and their duplication is controlled by the metabolism  of nutrients to species-specific pheromone blends that control reproduction. That fact makes sense of why there are copy number variants in neurons of the human brain and in unicellular yeasts. The molecular mechanisms that enable nutrient-dependent pheromone-controlled copy number variants are the same are the same.

 

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society