Deficiencies prevent repair: Mutagens and Multivitamins

Mutagens and Multivitamins

Not one to shy away from controversy, Bruce Ames has pitted himself against industry groups, environmentalists, and his peers through his work identifying DNA mutagens. And he’s not done yet.

By Megan Scudellari | June 1, 2014

Excerpt: So I started looking to see if you get DNA damage from a vitamin or mineral deficiency.” Beginning at Berkeley and continuing at Children’s Hospital Oakland Research Institute (CHORI), which Ames joined in 2000, he and his lab found many examples of this phenomenon: iron deficiency causes neuron decay and mitochondrial DNA damage, for example, and zinc deficiency damages DNA and disables tumor suppressor p53. But Ames still didn’t know how such deficiencies could directly damage DNA.

My comment: In my model, deficiencies prevent repair

 Nutrient-dependent/pheromone-controlled adaptive evolution: a model  led to an invited review of nutritional epigenetics that linked atoms to ecosystems. The invited review was rejected because no one would review it. I think it was too innovative in its refutation of neo-Darwinian mutation-initiated natural selection and the evolution of biodiversity. I focused on Darwin’s ‘conditions of life’ and linked nutrient uptake to pheromone-controlled reproduction via conserved molecular mechanisms that enable amino acid substitutions in species from microbes to man.

The links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of all species are as clear as they are in Patrick and Ames (2014) Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism, which was reported as New research indicates causal link between vitamin D, serotonin synthesis and autism. Simply put, you don’t arrive at socio-cognitive niche construction without ecological, social, and neurogenic niche construction, which explains activation of serotonin, oxytocin, and vasopressin by vitamin D.

If those three brain hormones that affect social behavior were not nutritionally activated, there could be no such thing as nutrient-dependent hormone-organized and hormone-activated behaviors like those we detailed in the context of cell type differentiation in From Fertilization to Adult Sexual Behavior. Unfortunately, even after extension of our model to invertebrates and the life cycle transitions of the honeybee, I may not get to publish another article — like Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems, which refutes the population geneticist’s ideas about mutations, natural selection and the evolution of biodiversity.

They would rather have people continue to believe that some mutations must be beneficial, although no experimental evidence ever suggested that perturbed protein folding created new functional proteins that were manifested in the morphological and behavioral phenotypes of any species. Hemoglobin S, for example, appears to involve a vitamin D-dependent amino acid substitution that stabilizes the organized genome in human populations where endemic malaria could otherwise have limited their adaptive radiation.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society