Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo
Its applications, countless, extend for example to the domain of chemicals able to trigger predetermined behaviors in mammals or in insects, such as pests, disease vectors or parasites. “Besides, it is not necessary to know the genome of the species studied, because only the gene transcripts, that is the RNA messengers, which are the gene ‘prints’, are analysed”, explains Ivan Rodriguez.
My comment: Why does anyone need to explain that the RNA-mediated mechanisms of cell type differentiation have been conserved across all living genera via the physiology of nutrient-dependent reproduction? Is there one serious scientists who does not already know that?
Is there one evolutionary theorist who will accept the facts known to serious scientists about the odor-induced de novo creation of olfactory receptor genes?
My comment: The epigenetic trap is nutrient-dependent and controlled by the physiology of reproduction. See for examples: Nutrient-dependent/pheromone-controlled adaptive evolution: a model.
See also, this invited review of nutritional epigenetics for the journal Nutrients.
Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.