Conserved molecular mechanisms: GnRH

Your eyes are half a billion years old [but your nose is older than that]

Excerpt: “Why are there many different kinds of eye, including one for insects and crustaceans – and one for vertebrates like us?”

My comment: See also: Kochman (2012)  “During 600 million years of animal evolution, the N and C termini of GnRH have been conserved as functional domains for binding and activating cognate receptors to accomplish its functions.” “It is very surprising and fascinating that the coordinated evolutionary selection of amino acids participating in binding GnRH has resulted in such perfection, that no substitution with a natural amino acid in any position improves binding potency.”  Despite the fact that amino acid substitutions yield differences in species that cannot be accounted for via random mutations theory, some theorists continue to claim we have evolved into primarily visual creatures via mutation-driven evoluton. However, GnRH links olfactory/pheromonal input directly to gene activation in neurosecretory neurons of brain tissue that are the biological core of mammalian reproduction. This puts the relative salience of visual input in humans into the same perspective as in all other animals. We cannot be primarily visual creatures, because there is no animal model that suggests anything other than the primacy of olfaction. “Olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans.” Those who insist on using the conservation of molecular mechanisms in development of the eye to tout the relative salience of visual input in humans seem unable to see past the nose on their face, which is 100 million years older than the ‘blind eyes’ they use to look at the world from their tainted perspective of mutation-driven evolution.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society