Excerpt: “…site-specific miRNA editing is an evolutionarily conserved mechanism, which increases the functional diversity of mammalian miRNA transcriptomes.”
Excerpt 2): “…miRNA editing is an integral and evolutionarily stable feature of mammalian transcriptomes.”
My comment: It’s time for social scientists and serious scientists alike to admit that site-specific miRNA editing is nutrient-dependent and pheromone-controlled. Biological facts continue to refute the pseudoscientific nonsense of mutation-initiated natural selection and evolved biodiversity.
Excerpt: “… pathogenic mtDNA mutations are usually present at low frequency and buffered by healthy mtDNA, preventing the action of natural selection.
My comment: Few people are willing to publicly admit that ecological variation results in ecological adaptations via conserved molecular mechanisms in species from microbes to man. However, removing the theory of mutation-initiated natural selection from any further consideration will help move science forward in the context of cell type differentiation via amino acid substitutions.
For example (from Kohl, 2013) : “In flies, ecological and social niche construction can be linked to molecular-level cause and effect at the cellular and organismal levels via nutrient-dependent changes in mitochondrial tRNA and a nuclear-encoded tRNA synthetase. The enzyme enables attachment of an appropriate amino acid, which facilitates the reaction required for efficient and accurate protein synthesis (Meiklejohn et al., 2013).”
Ecological variation is manifested in ecological adaptations via amino acid substitutions that differentiate cell types in all individuals of all species. Thus, the only stable feature of mammalian transcriptomes arises in the context of nutrient-dependent pheromone-controlled ecological adaptations, and not in the context of mutation-initiated natural selection.