Chromosomal rearrangements: What would earth be like if not for human pheromones?

Refining language for chromosomes

News article excerpt: “…advances in next-generation sequencing methods and results from BWH’s Developmental Genome Anatomy Project (DGAP) revealed an assortment of genes disrupted and dysregulated in human development in over 100 cases. Given the wide variety of chromosomal abnormalities, the researchers recognized that more accurate and full descriptions of structural chromosomal rearrangements were needed.”

Journal article excerpt: “The suggested nomenclature described herein is designed to provide an objective system to explain the structural rearrangements at a molecular level.”

My comment: This suggests to me that theorists will no longer be able to tell serious scientists that anything that happens to DNA is a mutation. The authors clarify the fact that unbalanced rearrangements could result from a deletion, duplication, addition, amplification, or a single derivative of a simple translocation.

“…they might also result from gains or losses accompanying translocations or inversions or even more complex rearrangements…”

Those who invoke theory and continue to simply explain away nutrient-dependent RNA-mediated amino acid substitutions and chromosomal rearrangements linked from bi-parental feeding in sparrows to different morphological and behavioral phenotypes will probably evoke laughter if they also try to discuss what they were taught to believe was a role for mutations in the evolution of species diversity associated with chromosomal rearrangements. Someone will almost undoubtedly ask: Did you ever consider the likelihood that sex chromosomes arose via conserved molecular mechanisms that appear to link sex differences in cell types from microbes, such as yeasts, to sex differences and sexual orientation in men and women?

Gilbert’s group, for example, found that humans could detect differences in odors associated with individual chromosomes from otherwise syngeneic mice, including on the basis (i) of differing X or Y chromosomes or (ii) of differences introduced as nonidentical MHC haplotype.

Later in life, Avery Gilbert was referred to as a human pheromone-denier by Leslie Vosshall, who recently co-authored Humans Can Discriminate More than 1 Trillion Olfactory Stimuli.

I’ve since wondered how he developed A Fear of Pheromones, since his 1996 findings were reported with senior author Lewis Thomas, who also wrote A Fear of Pheromones.

“WHAT are we going to do if it turns out that we have pheromones? What on earth would we be doing with such things? With the richness of speech, and all our new devices for communication, why would we want to release odors into the air to convey information about anything?” — Lewis Thomas (1971)

My comment: Conserved molecular mechanisms link the nutrient-dependent pheromone-controlled physiology of reproduction in species from microbes to man. Thus, the question Lewis Thomas posed has become: What would earth be like if not for human pheromones?

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society