Chemical ecology and RNA-mediated control of DNA loops

DNA Loop-the-Loops

A new full-genome map indicates how DNA is folded within the nuclei of human cells.By Kate Yandell | December 11, 2014

Excerpt: “…many loops were conserved among cell types, and even between mice and humans. But others seemed to drive cell type-specific gene expression patterns.”

My comment to The Scientist Magazine:

Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Excerpt: “A form of GnRH associated with sexual orientation in yeasts links control of the feedback loops and developmental processes required for nutrient acquisition, movement, reproduction, and the diversification of species from microbes to man [via RNA-directed DNA methylation and RNA-mediated amino acid substitutions that stabilize protein folding in the DNA of organized genomes].

I think this report on how DNA is folded within the nuclei of human cells makes it obvious that nutrient-dependent pheromone-controlled RNA-mediated amino acid substitutions, protein folding, and feedback loops link the epigenetic landscape to the physical landscape of DNA via what is currently known about the bio-physically constrained chemistry of protein folding and the conserved molecular mechanisms of cell type differentiation.

For cross species examples that include the honeybee model organism, see my 2012 and 2013 reviews, which are based on what we (T.B.) included in the molecular epigenetics section of our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior  and on extension of RNA-mediated cell type differentiation to insects in Organizational and activational effects of hormones on insect behavior and to the life history transitions of honeybees in Honey bees as a model for understanding mechanisms of life history transitions.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society