Biologically-based EES cause vs the pseudoscientific nonsense of SET

The EES expands what is recognized as causally relevant in the process of evolution

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Excerpt: “organisms inherit a wide variety of materials from their ancestors, including epigenetic marks, hormones, symbionts, learned knowledge and skills, and ecological legacies”

My comment: That is how organisms ecologically adapt. If there were not details of the RNA-mediated link from the epigenetic landscape to the physical landscape of DNA in species from microbes to man, the following statement would still represent a perspective that is not biologically based.

Excerpt:The best way to elevate the prominence of genuinely interesting phenomena such as phenotypic plasticity, inclusive inheritance, niche construction and developmental bias (and many, many others) is to strengthen the evidence for their importance.

My comment: RNA-directed DNA methylation links ecological variation to ecological adaptations via RNA-mediated events, which include the nutrient-dependent amino acid substitutions that differentiate all cell types in all tissues of all organs of all organ systems. If not for across species examples that link the epigenetic landscape to the physical landscape of DNA in species from microbes to man and the manifestations of the RNA-mediated links in morphological and behavioral phenotypes, evolutionary theorists and evolutionary theists could truthfully claim: “…that evolutionary biologists have been studying feedback between organisms and the environment for well over a century13.” Instead, they continue to misrepresent the fact that they understand nothing about “feedback between organisms and the environment”.

If ever they learn about the nutrient-dependent pheromone-controlled RNA-mediated events that clearly link ecological variation to increasing organismal complexity manifested in biodiversity, the theorists and theists will come face to face with what has been known about cell type differentiation for more than 40 years.  “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.” (p-127)

The molecular mechanisms that link the epigenetic landscape to the physical landscape of DNA via RNA-mediated events have become clear enough to link nutrient stress and social stress from ecological variation to ecological adaptations and biodiversity without claims about mutations, natural selection, or the evolution of biodiversity. See, for instance, H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress reported as:

Start signal for transcription of stressed genes identified

Excerpt 1): “…stress is “a psychological and physical reaction to external stimuli…”

My comment: “The newer and often redefined terms for pheromones limit the use of what is now known about their epigenetic effects, which are also associated with social stress on adaptively evolved socio-cognitive niche construction (Flinn, Nepomnaschy, Muehlenbein, & Ponzi, 2011; O’Connell & Hofmann, 2011, 2012; Whiten & Erdal, 2012). For example, social stress (see for review McEwen, 2012, 2013) associated with the absence of pheromones (Niwa et al., 2013) or with their presence and aggression (Barik et al., 2013) is as likely as nutrient-dependent stress associated with food acquisition to alter hormones and behavior during development. That is because the epigenetic effects of nutrient stress associated with food odors and the epigenetic effects of social stress associated with pheromones occur via the GnRH-controlled pathway, which includes both HPG axis and HPA axis regulation.” Kohl (2013)

Excerpt 2): “The study has not only identified histone phosphorylation as a hallmark of stress-activated genes, but also the mechanism by which this chromatin mark induces transcription of these genes on a molecular level.”

Identification of what occurs at the molecular level of stress-induced gene activation clearly links RNA-mediated amino acid substitutions to cell type differentiation in the context of Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems as detailed in this 5.5 minute long video presentation of  Nutrient-dependent / Pheromone-controlled adaptive evolution: (a mammalian model of thermodynamics and organism-level thermoregulation)

Claims that evolutionary theorists and evolutionary theists study or understand “feedback between organisms and the environment” can be addressed in the context of reports that link nutrient-stress via RNA-mediated transgenerational epigenetic inheritance to pheromone-controlled biodiversity without continuing to tout pseudoscientific nonsense.


Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans;

Signaling Crosstalk: Integrating Nutrient Availability and Sex

System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes

Feedback loops link odor and pheromone signaling with reproduction

See also for the importance of nutrient-dependent amino acid substitutions to cell type differentiation:

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society