Are pheromones responsible for human body odour assessment?

Can You Smell Yourself? by Sarah C. P. Williams on 22 January 2013, 5:10 PM

Excerpt: “Other molecules the human body produces could also influence individual smells and scent preferences, Zufall says. The individuality of people’s microbiomes—the collection of microbes living in and on us—could also be linked to the body’s odor or preferences, Wedekind says. “We just don’t know the full physiology yet,” he said, “But this is a good start.”

My comment: The full physiology has been detailed. The details are based on common molecular mechanisms and the epigenetic effects of nutrients and pheromones on individual survival and species diversification. Self vs non-self recognition is a function of the metabolism of nutrients to pheromones in species from microbes to man.

Major histocompatibility complex peptide ligands as olfactory cues in human body odour assessment

Excerpt 1: “… activation of particular brain regions by exposure… [reflects] ‘self’ or ‘non-self’ qualities relative to the individual’s MHC genotype.”

Excerpt 2: “…our study suggests that, as in mice and fish, sensory evaluation of MHC diversity through the recognition of structurally diverse MHC ligands may be involved in human MHC-associated behaviour.”

My reflection on their suggestion Gonadotropin releasing hormone (GnRH) emerged as a early regulator of reproduction. For example, the yeast α mating factor has 80% amino acid homology with mammalian GnRH. It also stimulates gonadotropin release from the mammalian pituitary.  The discovery of the fact that one decapeptide molecule, among the GnRHs, was constructed perfectly at the beginning of 400 million years [of vertebrate] evolution and that it is not possible to improve its physiological potency using the any natural amino acid is, in my opinion, important….”  It may also be important to note that mice and sticklebacks are vertebrates.

We can then look at an earlier work  with a 2004 Nobel Laureate as a co-author. We find evidence that Feedback loops link odor and pheromone signaling with reproduction.  The link is GnRH. “Indications that GnRH peptide plays an important role in the control of sexual behaviors suggest that pheromone effects on these behaviors might also involve GnRH neurons.”

The statement above translates to: The epigenetic effects of vertebrate pheromones on GnRH links nutrient-dependent pheromone production and RNA-mediated feedback loops to food odors and to pheromones, which control of reproduction in species from microbes to man.  Are pheromones anything less than the most powerful influence on the adaptive evolution of human behavior?

In Milinski et al (2013), human pheromones are body odors. The body odors of all other animals are pheromones.  Does the refusal to acknowledge the role of human pheromones in adaptively evolved human behavior exemplify academic nonsense, or ignorance of the full physiology that links nutrient – dependent pheromone-controlled reproduction to behavior in species from microbes to man?

Also see: Researchers crack olfactory code for partner selection, synthesise first biologically effective perfume

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society