Alternative splicings (very technical)

From time to time I try to update my knowledge base on specific aspects included in my model. Here is the link to an open access article that may be of interest to others who want to learn more about biologically based cause and effect. This is not the type of information that you are likely to see in news reported by science journalists.

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

Excerpt 1) DNA methylation and MeCP2 binding are likely to influence pre-mRNA splicing patterns directly. In addition, nucleosome positioning has been suggested to play a role in pre-mRNA splicing31.

Excerpt 2) Mutations in the gene encoding MeCP2 primarily account for the debilitating neurodevelopmental disorder Rett syndrome (RTT), an autism spectrum disorder33,34. Mouse models of RTT exhibit RNA splicing defects22; however, whether these defects are relevant to human disease has yet to be investigated. Misregulation and sequence variants of MeCP2 are found in patients with autism spectrum disorders23,35 and the autoimmune disorder systemic lupus erythematosus36, respectively. Abnormal DNA methylation contributes to the etiology of these diseases37,38,39. Our study implicates the loss of function of DNA methylation and MeCP2 as a cause of altered pre-mRNA splicing, which could potentially contribute to disease development40, a possibility that warrants further investigation.

My comment: It will not get much clearer. Mutations cause disorders and diseases by altering pre-mRNA splicing.

Typically, alternative splicings are epigenetically controlled.

Control is good.

Mutations are bad.

Questions for theorists and philosophers.

1) What controls alternative splicings so that mutations do not perturb adaptations to the environment?

2) What made you think that mutations cause the adaptations?

In my model, adaptations are nutrient-dependent and pheromone-controlled. Experimental support for my model is overwhelming. Experimental support for mutation-driven evolution does not exist. Intragenic DNA methylation leads to indirect genetic effects (IGEs) via Genome Dynamics Events (GDE) but ecological adaptations occur only via RNA-mediated events that do not cause mutations.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society