Aging Is Recorded in Our Genes

This news story is available at: news.sciencemag.org. Today’s news from Science and ScienceInsider Mon, 11 June 2012

Aging Is Recorded in Our Genes
As we grow older, we lose DNA modifications that can protect against cancer and other diseases.

Excerpt:  … likens the DNA sequence to the genome’s “hardware” and epigenetic changes to its “software,” … supports earlier research suggesting that “as a function of age and environmental exposure, this software accumulates defects” that can cause “age-related cancer and degenerative diseases.”

My Comment:

This seems to be a clear indicator that the epigentic effect of nutrient chemicals on intracellular signaling and stochastic gene expression is central to what shows up in degrees of methylation. Is there any consensus that this is predicted by the direct effect of nutrient chemicals on receptor-mediated events, like those initiated by glucose in neurosecretory neurons of the mammalian hypothalamus that secrete gonadotropin releasing hormone (GnRH)? These hormone-secreting nerve cells of brain tissue link sensory input from our environment directly to a neurogenic niche that controls the wiring of the brain prenatally and postnatally.

Like other animals our sense of smell links food odors and social odors directly to postnatal GnRH regulation of the hypothalamic-pituitary-gonadal (HPG) axis and the HP-adrenal (HPA) axis. And our sense of smell is the first indicator of several neurodegenerative age-related diseases, as well as a likely indicator of neuroproliferation problems like those now being recognized in autism spectrum disorders (ASDs).

Measures of luteinizing hormone (LH) during the development of the brain and behavior seem to be the best indicator of what happens with aging. Simply put, LH is the link between nutrient chemicals, pheromones, hypothalamic neurogenesis, olfactory bulb neurogenesis, hippocampal neurogenesis, learning, memory, and behavior — as modeled across the ecological, social and neurogenic niche construction that contribute to the adaptive evolution of our cognitive niche.

But our cognitive niche won’t do us much good until we hone our collective pattern-recognition skills. For example, olfaction and odor receptors provide a clear evolutionary trail that can be followed from unicellular organisms to insects to humans, and the trail includes the epigenetic effects of nutrient chemicals and pheromones on methylation in species from microbes to man.  Of course, these effects extend to transgenerational epigenetic inheritance and speciation, but I may have taken this too far, already.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society