Adaptive evolution via epigenetic effects on a single gene

Subscription required: Science 15 March 2013: Vol. 339 no. 6125 pp. 1312-1316

Adaptive Evolution of Multiple Traits Through Multiple Mutations at a Single Gene

Catherine R. Linnen, Yu-Ping Poh, Brant K. Peterson, Rowan D. H. Barrett, Joanna G. Larson, Jeffrey D. Jensen, Hopi E. Hoekstra

Abstract Excerpt: “…local adaptation is the result of independent selection on many mutations within a single locus, each with a specific effect on an adaptive phenotype, thereby minimizing pleiotropic consequences.”

My comment (submitted 3/14/13 approved 4/5/13):

In the context of adaptive evolution, Linnen et al.,reminds us to look at models of genes with large effects for comparison to random mutations theory. For example, using the molecular mechanisms common to all species and exemplified in the mouse, the time from pleiotropy to epistasis in a human population appears to be approximately 30,000 years (Kamberov et al., 2013; Grossman et al., 2013). Perhaps epistasis requires only one nutrient-dependent pheromone-controlled amino acid substitution. That likelihood led me to look at pleiotropy, amino acid substitutions, and epistasis in several different model organisms via the common molecular mechanisms of “Nutrient-dependent / Pheromone-controlled thermodynamics and thermoregulation.

I moved quickly from microbes to nematodes, insects, and mammals. Receptor-mediated mouse to human examples of how nutrient-dependent amino acid substitutions can be readily linked to pheromone-controlled reproduction via common molecular mechanisms become as clear as they are in the honeybee model organism. What the queen eats determines her pheromone production and everything else about the interactions in the colony, including the development of the worker bees brain. The epigenetic effects occur sans mutations, which tends to refute the multiple mutations approach to adaptive evolution and replace theory with a model. In the model, natural selection is for nutrients that metabolize to pheromones. The pheromones control reproduction and link epigenetic effects on the microRNA/messenger RNA balance from stochastic gene expression to behavior and back.

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society