A nutrient chemical and pheromone-dependent neurogenic niche

The article linked below offers the first evidence I have seen for a diet-responsive neuogenic niche.

Weight struggles? Blame new neurons in your hypothalamus.” May 21st, 2012.

Excerpt: “People typically think growing new neurons in the brain is a good thing – but it’s really just another way for the brain to modify behavior,” Blackshaw explains. He adds that hypothalamic neurogenesis is probably a mechanism that evolved to help wild animals survive and helped our ancestors do the same in the past.”

My comment:

In my model nutrient chemicals and pheromones have direct effects on hypothalamic neurogenesis, olfactory bulb neurogenesis, and hippocampal neurogenesis. These direct effects link nutrient chemicals and pheromones to the biological core of mammalian reproduction: the hypothalamic gonadotropin releasing hormone (GnRH) pulse.

In mammals, for example, food odors and pheromones cause changes in GnRH pulse frequency that result in patterns of neurogenesis responsible for the development of behaviors associated with proper food choice (individual survival) and proper mate choice (species survival). Food odors up-regulate and social odors down-regulate the calibration of stochastic gene expression responsible for control of speciation via hippocampal neurogenesis and the required learning and memory of species specific behaviors.

The direct effect of food odors and social odors on signalling pathways makes the epigenetic effects of chemical cues as important to the understanding of human behavior as they are to the understanding of behavior in every other species. This is especially true for placental mammals.

The in utero and postnatal effect of the chemical stimuli is on the development of the hypothalamic GnRH neuronal niche, which is responsible for the conditioning of food preferences and mate preferences and the transgenerational epigenetic inheritance of all behaviors required for individual and species survival.  GnRH-dependent luteinizing hormone (LH) secretion, for example, is the link between proper nutrition and reproductive sexual behavior. The feedback loops are detailed in my model for the adaptive evolution of the human brain and behavior.

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society