A newly discovered hypothalamic neurogenic niche in the brain

A new type of nerve cell found in the brain

Article excerpt (from Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions): “In this study we show that both thyroid hormone receptors are required for the development of a previously unknown population of parvalbuminergic cells in the anterior hypothalamus. Our data link for the first time to our knowledge defects in thyroid hormone signaling during development to a permanent cellular alteration in the hypothalamus. Moreover, as the cells are associated with the control of cardiovascular function, our study shows that developmental hypothyroidism may represent a previously unknown risk factor for cardiovascular disorders.”

The article addresses, in part, neurogenic niche construction in a manner similar to how ecological, social, and socio-cognitive niche construction are addressed in my model of nutrient-chemical dependent, pheromone-controlled, receptor-mediated adaptive evolution that links microbes to man. For example, it is hard for me to imagine that this previously unknown population of parvalbuminergic cells in the anterior hypothalamus does not interact with the neurosecretory neurons of the medial preoptic area of the anterior hypothalamus that control secretion of gonadotropin releasing hormone (GnRH): THE biological core of ALL behavior  (e.g., in vertebrates). But perhaps the problem for me is because I know there’s a model for that!

These authors rightfully claim, however, that they are the first to “…identify a permanent cellular defect in the hypothalamus resulting from developmental hypothyroidism and add hypertension to the list of symptoms potentially arising from maternal hypothyroxinemia and/or congenital hypothyroidism.”  They are among many, however, who seem to  have missed a likely epigenetic link from maternal and/or acquired ferritin deficiency to thyroxine transport, brain development, and behavior. Perhaps they don’t know there’s a model for that!

About James V. Kohl 1308 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society