A thought experiment

I may be confused about proximate and ultimate cause, especially if the role of transgenerational epigenetic inheritance is not central to the extended evolutionary synthesis. Isn’t transgenerational epigenetic inheritance the problem that led Dickins and Rahman to suggest a thought experiment; one where epigenetic mechanisms introduce shifts in learning bias for certain associations as would endocrine functioning? If so, my model (Kohl, 2012), which combines the epigenetic effects of nutrient chemicals and pheromones with biased endocrine functioning and adaptive evolution, may help move the modern synthesis forward.

I tried this before, but the evolutionary continuum from microbes to man (Kohl, 2007) seems too much to grasp in the context of biased endocrine functioning. However, the honeybee has since emerged as a model organism to exemplify nutrient chemical and pheromone-dependent epigenetic alterations in endocrine functioning. These epigenetic effects that bias endocrine functioning are required for the adaptive evolution of reproduction.

Reproduction is required for transgenerational epigenetic inheritance and species diversity, which is perhaps better represented in the threespine stickleback vertebrate model organism. However, in all invertebrate and vertebrate model organisms, nutrient chemicals establish the ecological niche of individuals, and the presence of conspecifics establishes their social niche (as also occurs with microbial species).

The honeybee best exemplifies how  ecological and social niches contribute to the hypothalamic gonadotropin releasing hormone (GnRH) neurogenic niche that is responsible for the adaptive evolution of the human brain. Simply put, what the queen eats determines her pheromone production and everything else about the social interactions in the colony, including the required epigenetic effects of pheromones on the neuroanatomy of the worker bee’s brains during the development of their diverse behaviors that change with exposure to different chemical input associated with a variety of other sensory input of lesser importance / salience.

Of course, that sounds too simple in the context of the extended evolutionary synthesis and human brain evolution. But the molecular biology is conserved across species, which is helpful for proof of concept. In placental mammals, for example, in utero nutrient chemical transfer is responsible for organization of the brain’s postnatal activation by nutrient chemicals and pheromones. The proper GnRH-driven behavioral response of the infant to activation by these chemicals ensures its survival, just as the proper response of the honeybee worker bee’s brain to nutrient chemicals and pheromones ensures its survival and helps to ensure the colony’s survival via changes in the neuroanatomy of its brain. (Parenthetically, spectral input may or may not be correlated with direct epigenetic effects on the brain, but it is not causal to brain development.)

Model organisms have their RNA-mediated molecular biology in common with all other organisms. No organism survives in the absence of sufficient nutrient chemicals. Ecological niches contract. And no species survives in the absence of reproduction controlled by pheromones. I think that’s why we are now seeing more reports on transgenerational epigenetic inheritance, with causal links to speciation via ecological and social niches in all species. We should soon see the addition of neurogenic niches in many others.

What I don’t see is anyone who is integrating the ecological, social, and neurogenic niches and considering the epigenetic effects of nutrient chemicals and pheromones in the context of endocrine disruption and transgenerational epigenetic inheritance. Nutrient chemicals and pheromones promote homeostasis and also allow adaptive evolution, including adaptive evolution of the human brain. Endocrine disruption causes atypical development of the brain and the body.

Isn’t that the apparent design we might all someday see in biology? Isn’t seeing the apparent design required to move forward from the Modern Synthesis to the Extended Evolutionary Synthesis?

Jim Kohl
www.pheromones.com

On 5/27/2012 3:26 AM, R.J.King@lse.ac.uk wrote:

jvkohl:
I fear that you may have confused proximate and ultimate. Easily done. Epigenetics, while fascinating, has no impact on the central doctine of genes as the sole information carriers. Epigenetics are just one more set of mechanisms by which genes achieve their ultimate aim of replication. I.e. they are part of the suite of adaptations. The University of Utah has an excellent site detailing this
https://learn.genetics.utah.edu/
May I particularly recommened this page which beautifully illustrates the way in which behaviours and epigenetics intereact in this way to calibrate personality to environment?
https://learn.genetics.utah.edu/content/epigenetics/rats/
My suspicion  is that the folk biology concept of "biology=fixed at birth" dies very very hard and keeps recurring in odd forms in even the best and brightest of us.
About James V. Kohl 1307 Articles
James Vaughn Kohl was the first to accurately conceptualize human pheromones, and began presenting his findings to the scientific community in 1992. He continues to present to, and publish for, diverse scientific and lay audiences, while constantly monitoring the scientific presses for new information that is relevant to the development of his initial and ongoing conceptualization of human pheromones. Recently, Kohl integrated scientific evidence that pinpoints the evolved neurophysiological mechanism that links olfactory/pheromonal input to genes in hormone-secreting cells of tissue in a specific area of the brain that is primarily involved in the sensory integration of olfactory and visual input, and in the development of human sexual preferences. His award-winning 2007 article/book chapter on multisensory integration: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences followed an award winning 2001 publication: Human pheromones: integrating neuroendocrinology and ethology, which was coauthored by disinguished researchers from Vienna. Rarely do researchers win awards in multiple disciplines, but Kohl’s 2001 award was for neuroscience, and his 2007 “Reiss Theory” award was for social science. Kohl has worked as a medical laboratory scientist since 1974, and he has devoted more than twenty-five years to researching the relationship between the sense of smell and the development of human sexual preferences. Unlike many researchers who work with non-human subjects, medical laboratory scientists use the latest technology from many scientific disciplines to perform a variety of specialized diagnostic medical testing on people. James V. Kohl is certified with: * American Society for Clinical Pathology * American Medical Technologists James V. Kohl is a member of: * Society for Neuroscience * Society for Behavioral Neuroendocrinology * Association for Chemoreception Sciences * Society for the Scientific Study of Sexuality * International Society for Human Ethology * American Society for Clinical Laboratory Science * Mensa, the international high IQ society