Tag Archive: substitutions

Ecological validity vs evolutionary theory

Genetic code

Functional characterisation of a SNP in the ABCC11 allele—Effects on axillary skin metabolism, odour generation and associated behaviours Excerpt: …the fact that a single SNP plays such a large role in governing this specific aspect of human behaviour is quite…
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Implicating microRNAs in cancer

terrarium eco system

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis Reported as: In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution Excerpt: “Unexpectedly, the screen also implicated several microRNAs — small RNA segments that are…
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Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs

terrarium eco system

Of Cells and Limits Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement. By Anna Azvolinsky | March 1, 2015…
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Reverse phosphorylation

Genetic code

See for review: Let there be anti-entropic light (1)   Squid are hyper-editors when it comes to RNA This is a great summary of what is currently known about anti-entropic light and nutrient-dependent RNA-mediated pheromone-controlled cell type differentiation. Excerpt: “During…
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RNA-mediated repurposing in microbes and adapations in primate brains

human-evolution

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion Excerpt: “…the C-terminal 47 amino-acids of ARHGAP11B (after lysine-220) constitute not only a unique sequence, resulting from a frameshifting deletion (fig. S10), but also are functionally distinct from their counterpart…
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RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled

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 Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system Excerpt: The fast-spreading strain AR2F had acquired an additional point mutation in the σ54-dependent EBP gene ntrC, which alters an amino acid (R442C) within the DNA binding domain…
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Let there be anti-entropic light (1)

terrarium eco system

Summary: Light-induced amino acid substitutions link cell type differentiation in plants to nutrient-dependent pheromone-controlled reproduction in animals via the biophysically constrained chemistry of protein folding. Protein folding is perturbed by mutations that limit the ability of organisms to adapt to…
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Atheism: Arrogant, useless, and divisive ignorance

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Scientific Seeker Stuart Kauffman on Free Will, God, ESP and Other Mysteries By John Horgan | February 4, 2015 Excerpt: Horgan: What do you make of the antipathy toward religion expressed by Richard Dawkins and other “New Atheists?” Kauffman: … moral…
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Nutritional epigenetics, exercise, and immune system integrity

terrarium eco system

Anti-inflammatory mechanism of dieting and fasting revealed Summary: Researchers have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes,…
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What if Darwin was not still dead?

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What Would Darwin Think About Modern Darwinism? Excerpt: “Imagine if Darwin could be transported to the present and learn what has become of his theory. What would excite him the most? Would anything disturb or disappoint him? TVOL has polled…
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