Tag Archive: pre-mRNA

Let there be anti-entropic light (2)

Physics

Without knowing anything about the biophysically constrained chemistry of protein folding that links light-induced amino acid substitutions to the stability of DNA is the organized genomes from plants via bioluminescent bacteria in squid, the pattern of nutrient-dependent biologically-based cause and…
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Olfaction, ecology, and intelligence

rp_poster-from-jesse.jpg

“I should think we might fairly gauge the future of biological science, centuries ahead by estimating the time it will take to reach a complete comprehensive understanding of odor. It may not seem a profound enough problem to dominate all…
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From Hydra to humans vs a Lakatosian research program

translocated chromosome

Imre Lakatos Excerpt: “A Lakatosian research programme[8] is based on a hard core of theoretical assumptions that cannot be abandoned or altered without abandoning the programme altogether. More modest and specific theories that are formulated in order to explain evidence…
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Dual genomes: exposing the evolution industry

genetic code RNA medium

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes Excerpt: “The CDP showed a significant overrepresentation of certain gene ontology (GO) groups (global tests Po0.001–0.009), using the programme FUNC23 (Methods). These groups included GPCRs, in particular olfactory receptors…
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Epigenetic pharmacology and RNA-mediated transciptional landscapes

terrarium eco system

Last year, Vosshall’s group eliminated ideas about the involvement of beneficial mutations in the nutrient-dependent cell type differentiation of mosquitoes. orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET. This year her group showed…
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More than a bag of chemicals?

neuronal-plasticity

From Fertilization to Adult Sexual Behavior (1996) Excerpt: “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…” My comment:…
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RNA eclipses the importance of DNA to cell type differentiation

genetic code RNA medium

Why skin cells are skin cells and not neurons Excerpt: “…we’re using this approach to identify how the epigenome changes when plants are exposed to challenging environmental conditions, such as drought or high temperature, and how these changes might prime…
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Pharmacogenomics

genetic code RNA medium

“The gene, cell, tissue, organ, organ-system pathway is a neuroscientifically established link between sensory input and behavior. Marts and Resnick (2007) stress the importance of this pathway in the context of a systems biology approach to pharmacogenomics.” (Kohl, 2012) “Naftolin…
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It’s cell type differention, not cell fate determination (2)

genetic code RNA medium

See: It’s cell type differention, not cell fate determination High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions Excerpt: “…deviation from the derived models is a characteristic hallmark of methylation changes associated with…
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Are evolutionary theorists ‘nob ends’?

The past is not the key to the present

Interview – Prof Brian Cox and Robin Ince Robin Ince “Am I wrong to sometimes be scared of science idiots?” Brian Cox  “…my favoured response would be: ‘you bunch of utter nob ends’.  See also:  “The problem with today’s world…
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