Tag Archive: mutation-driven

RNA-mediated epigenetic modification via DNA-methylation

human-evolution

I have repeatedly used the phrase “RNA-directed DNA methylation and RNA-mediated amino acid substitutions” in the context of links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. See…
Read more

ISHE’s human ethology group

terrarium eco system

On January 7, 2015, the moderator of the ISHE’s human ethology yahoo group posted this notice to the group. RNA-mediated epigenetic regulation of gene expression D Holoch, D Moazed – Nature Reviews Genetics, 2015 Diverse classes of RNA, ranging from small to…
Read more

Targeting a cancer gene

human-evolution

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous…
Read more