Tag Archive: microbes to man

De novo creation of olfactory receptor genes

terrarium eco system

Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo Reported as:  Deciphering the olfactory receptor code Excerpt: Its applications, countless, extend for example to the domain of chemicals able to trigger predetermined behaviors in mammals or in insects,…
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Ecological validity vs evolutionary theory

Genetic code

Functional characterisation of a SNP in the ABCC11 allele—Effects on axillary skin metabolism, odour generation and associated behaviours Excerpt: …the fact that a single SNP plays such a large role in governing this specific aspect of human behaviour is quite…
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From 3-D to epigenetically-effected 4-D genome make-up

terrarium eco system

Discoveries in 3-D Genome Make-Up and Genetic Changes: Clarification of differences amidst chromosome pairs and how gene expression is effected by chromosome folding Excerpt: “…offers a useful guide for future studies of the epigenome’s function in our evolution and diseases…
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The anti-entropic force of “Nature”

Physics

Exploring the Epigenome A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks. By Jenny Rood | February 18, 2015 Excerpt:  “All our cells have a copy of the same book, but they’re all reading…
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RNA-mediated epigenetic modification via DNA-methylation

human-evolution

I have repeatedly used the phrase “RNA-directed DNA methylation and RNA-mediated amino acid substitutions” in the context of links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. See…
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All of “like kind” (Part 2)

human-evolution

See: All of “like kind” in the (bigger) family I’ve since tried, but failed, to succinctly express my thoughts about representations in the article All in the (bigger) family. I exceeded the allowable word count. Here they are, in the…
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Beneficial microbes kill beneficial mutations

genetic code RNA medium

Microbiology: Here’s looking at you, squid Margaret McFall-Ngai has dissected the relationship between a beautiful squid and its live-in bacteria — and found lessons for microbiome research on the way. Ed Yong 14 January 2015 Excerpt: “We now know that…
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Constrained evolution is ecological adaptation

translocated chromosome

See also: Unconstrained evolutionary innovability Ideas that evolution is not constrained can be compared to experimental evidence of biophysically constrained ecological adaptations. The most recent relevant open access published work from the Jakobsson lab is: TRIM28 Represses Transcription of Endogenous…
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A single amino acid substitution differentiates cell types of E. coli

Genetic code

Rare amino acid influences E. coli infection Excerpt: “They found that E. coli O157 is unable to attach itself to host tissue in high concentrations of D-Serine. Other strains, such as those that cause meningitis, thrive in the presence of…
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Models by evolutionary biologists are not models

terrarium eco system

How Networks Are Revolutionizing Scientific (and Maybe Human) Thought By John Edward Terrell, Termeh Shafie and Mark Golitko | December 12, 2014 | Excerpt: “…evolutionary biologists are now modeling series of complex networked relationships at multiple levels ranging from individual “letters”…
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