Tag Archive: metabolism

Ecological validity vs evolutionary theory

Genetic code

Functional characterisation of a SNP in the ABCC11 allele—Effects on axillary skin metabolism, odour generation and associated behaviours Excerpt: …the fact that a single SNP plays such a large role in governing this specific aspect of human behaviour is quite…
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Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs

terrarium eco system

Of Cells and Limits Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement. By Anna Azvolinsky | March 1, 2015…
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All of “like kind” in the (bigger) family

achiral glycine

All in the (bigger) family Science 16 January 2015: Vol. 347 no. 6219 pp. 220-221 DOI: 10.1126/science.347.6219.220 by Elizabeth Pennisi Abstract: A decade of genetic data and other evidence has persuaded most researchers that insects and crustaceans, long considered widely…
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Dual genomes: exposing the evolution industry

genetic code RNA medium

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes Excerpt: “The CDP showed a significant overrepresentation of certain gene ontology (GO) groups (global tests Po0.001–0.009), using the programme FUNC23 (Methods). These groups included GPCRs, in particular olfactory receptors…
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Epigenetic pharmacology and RNA-mediated transciptional landscapes

terrarium eco system

Last year, Vosshall’s group eliminated ideas about the involvement of beneficial mutations in the nutrient-dependent cell type differentiation of mosquitoes. orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET. This year her group showed…
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Thermodynamic constraints and ecological adaptations sans evolution

Physics

Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites Excerpt: “…a two-variable model that combines stability and stress signi ficantly improves predictions. Therefore, both the overall stability [symbol] and the stress [symbol] seem to capture distinct thermodynamic constraints on…
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Pharmacogenomics

genetic code RNA medium

“The gene, cell, tissue, organ, organ-system pathway is a neuroscientifically established link between sensory input and behavior. Marts and Resnick (2007) stress the importance of this pathway in the context of a systems biology approach to pharmacogenomics.” (Kohl, 2012) “Naftolin…
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A model of MHC ‘evolution’

thinking forbidden

Sexual selection and the evolutionary dynamics of the major histocompatibility complex Excerpt: “Here, we present the results of the first model of MHC evolution incorporating both survival and reproduction, modelling the combined effects of natural selection and MHC-based disassortative mating…
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ALPHA GENOMIX

genetic code RNA medium

ALPHA GENOMIX LABORATORIES INC Alpha genomics (for those unfamiliar with their spelling) Re: On this team, Dr. Hani El Shawa, is also first author of Prenatal Ethanol Exposure Disrupts Intraneocortical Circuitry, Cortical Gene Expression, and Behavior in a Mouse Model…
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Nutrient-dependent gene duplication in plants (but not animals?)

genetic code RNA medium

Divergence of Gene Body DNA Methylation and Evolution of Plant Duplicate Genes Excerpt 1) “A recent study demonstrated that the DNA methylation in promoter may play a significant role for functional divergence of duplicated genes in human [48].” Excerpt 1…
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