Tag Archive: epistasis

Let there be anti-entropic light (2)

Physics

Without knowing anything about the biophysically constrained chemistry of protein folding that links light-induced amino acid substitutions to the stability of DNA is the organized genomes from plants via bioluminescent bacteria in squid, the pattern of nutrient-dependent biologically-based cause and…
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Modeling conserved microRNA expression

translocated chromosome

Insects as models to study the epigenetic basis of disease Excerpt: “…selected insects can be used as models for human diseases with an epigenetic component because the underlying molecular mechanisms (DNA methylation, histone acetylation and the expression of microRNAs) are…
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From 3-D to epigenetically-effected 4-D genome make-up

terrarium eco system

Discoveries in 3-D Genome Make-Up and Genetic Changes: Clarification of differences amidst chromosome pairs and how gene expression is effected by chromosome folding Excerpt: “…offers a useful guide for future studies of the epigenome’s function in our evolution and diseases…
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Imagining that data historically supports evolutionary theory

human-evolution

1) Arguments in the evo-devo debate: say it with flowers! Abstract excerpt: A key question in evolutionary developmental biology is how DNA sequence changes have directed the evolution of morphological diversity. The widely accepted view was that morphological changes resulted…
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Thermodynamic constraints and ecological adaptations sans evolution

Physics

Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites Excerpt: “…a two-variable model that combines stability and stress signi ficantly improves predictions. Therefore, both the overall stability [symbol] and the stress [symbol] seem to capture distinct thermodynamic constraints on…
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No excuses: Creation and the meaning of organismal complexity

rp_poster-from-jesse.jpg

E.O. Wilson On ‘The Meaning Of Human Existence’ Excerpt: “We’re one species — glorious though we are — we are just one species out of an estimated eight million,” Wilson said. “At the present time, we only know almost exactly…
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Genomic surveillance ends our world of RNA-mediated ecological adaptations

social interaction and brain

Why is this woman smiling? 1) Identifying Recent Adaptations in Large-Scale Genomic Data Senior author: Sabeti with co-author Rinn Excerpt: “As natural selection can only act on mutations that drive phenotypic variation…”. 2) Genomic surveillance elucidates Ebola virus origin and…
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Mathematical model: microRNA and epigenetic regulation

Genetic code

Hypothesis & Theory ARTICLE Front. Genet. | doi: 10.3389/fgene.2014.00345 Interplay of microRNA and epigenetic regulation in the human regulatory network. Excerpt: “…a detailed model of the epigenetic interaction and its relations with the cellular environment would be required, and this…
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What causes evolution?

terrarium eco system

See also: The irony and confusion of molecular epigenetics. This is a follow-up Re: Epistasis and Allele Specificity in the Emergence of a Stable Polymorphism in Escherichia coli Abstract excerpt: “Ecological opportunities promote population divergence into coexisting lineages.” My comment: I’ve…
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Darwinian theories vs Darwin’s facts

rp_poster-from-jesse.jpg

“Darwin’s Theories“, submitted by Celia Secades of the Elesapiens website was the runner-up in the Third Annual NESCent Evolution Video Contest. (unfortunately, the video has been removed — perhaps for good reasons. For example: My comment: No experimental evidence supports the representations of mutation-initiated…
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