Tag Archive: epigenetic landscape

From 3-D to epigenetically-effected 4-D genome make-up

terrarium eco system

Discoveries in 3-D Genome Make-Up and Genetic Changes: Clarification of differences amidst chromosome pairs and how gene expression is effected by chromosome folding Excerpt: “…offers a useful guide for future studies of the epigenome’s function in our evolution and diseases…
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The anti-entropic force of “Nature”

Physics

Exploring the Epigenome A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks. By Jenny Rood | February 18, 2015 Excerpt:  “All our cells have a copy of the same book, but they’re all reading…
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RNA-mediated epigenetic modification via DNA-methylation

human-evolution

I have repeatedly used the phrase “RNA-directed DNA methylation and RNA-mediated amino acid substitutions” in the context of links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man. See…
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All of “like kind” (Part 2)

human-evolution

See: All of “like kind” in the (bigger) family I’ve since tried, but failed, to succinctly express my thoughts about representations in the article All in the (bigger) family. I exceeded the allowable word count. Here they are, in the…
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Environment epigenetically shapes the immune system

human-evolution

Environment, more than genetics, shapes immune system 1) –with my emphasis Re: “There’s nothing here that is revolutionary or requires rethinking of our assumptions about how the immune system functions…” My comment: They removed assumptions about cell type differentiation by…
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Unified nutritional and molecular mechanisms

terrarium eco system

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits Article image: Excerpt: “…unifying nutritional and molecular mechanisms remain elusive.” Reported as Molecular mechanism behind health benefits of dietary restriction identified Excerpt 1) “Dietary restriction is a type of intervention…
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Chemical ecology and RNA-mediated control of DNA loops

terrarium eco system

DNA Loop-the-Loops A new full-genome map indicates how DNA is folded within the nuclei of human cells.By Kate Yandell | December 11, 2014 Excerpt: “…many loops were conserved among cell types, and even between mice and humans. But others seemed…
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Are evolutionary theorists ‘nob ends’?

The past is not the key to the present

Interview – Prof Brian Cox and Robin Ince Robin Ince “Am I wrong to sometimes be scared of science idiots?” Brian Cox  “…my favoured response would be: ‘you bunch of utter nob ends’.  See also:  “The problem with today’s world…
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Nutrient-dependent gene duplication in plants (but not animals?)

genetic code RNA medium

Divergence of Gene Body DNA Methylation and Evolution of Plant Duplicate Genes Excerpt 1) “A recent study demonstrated that the DNA methylation in promoter may play a significant role for functional divergence of duplicated genes in human [48].” Excerpt 1…
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Evolutionary theorists and evolutionary theists live under rocks

terrarium eco system

CRISPR/Cas: Not Just for DNA Anymore Excerpt 1) “Unless you’ve been living under a rock the past two years, you’ve heard of CRISPR/Cas9, an RNA-guided nuclease that’s redefining synthetic biology and genome engineering.” Excerpt 2) “The authors propose several additional…
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