Tag Archive: cell type differentiation

Vitamin C and Tet-mediated changes

neuronal-plasticity

Timothy W. Bredy’s group just made a giant step forward from ‘Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation.’ With publication of ‘Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation‘ they bring to bear what…
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Not focused and self-aggrandizing

human-evolution

Abstract: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the…
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Chromosomal rearrangements and ecological adaptations (part 2)

translocated chromosome

I apologize for some of the repetition in the following post. Now that I have a reprint of the latest work from Donna Maney’s lab, I have more to say about it, and will again place it into context. “Ecological…
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Targeting a cancer gene

human-evolution

‘Undruggable’ mutation meets its match: Six-year effort yields first drug to target important cancer gene See also: Drug discovery: Pocket of opportunity[subscription required] Excerpt: “.,.the non-mutated protein is the beating heart of cell signalling, but mutated versions are the villainous…
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Pheromone-controlled thermodynamics and cancer

diseases-disorders

“If you learnt evolutionary biology and genetics a decade or more ago you need to be aware that those debates have moved on very considerably, as has the experimental and field work on which they are based.” — Denis Noble…
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