Sneaking up from behind

ISHE 2013 Poster photo
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I’ve been busy following the current research and attempting to discuss it, which led me to not finish this blog post. I started writing it last week. Since then, as I had anticipated, others have tried to sneak up from behind and stake their claims to links from physics to cell type differentiation that I have already detailed. Before moving forward with explanations on the role of light-induced amino acid substitutions in a follow-up blog post, I’ll post this now with a caution to those who try to pirate my works. Don’t do it unless you first understand enough about systems biology to avoid claims like the one Matti Pitkanen made.

He claimed that light-induced RNA-mediated changes somehow led to the simultaneous emergence of chickens and their eggs. See for instance: Was ribosome the first self-replicator? It may be best to download the PDF, since he may remove his blog post due to his embarrassment. (I have a copy of the PDF that I downloaded).

He wrote (emphasis mine): “Can one tell whether it was pro-cell or bio-molecules that emerged first? It seems that all these structures could have emerged simultaneously. What emerged was dark matter and its emergence involved the emergence of all the others. Hens and eggs emerged simultaneously.

————————————————————-Last week I wrote:

The invited review of nutritional epigenetics linked below was returned was returned without review. My questions to physicists about aspects of quantum biology remain unanswered, which makes it clear that researchers from yet another discipline intend to try to sneak up from behind me and claim that they already knew everything I have detailed during 20 years of published works.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

Abstract excerpt: This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man.

Physicists won’t admit that light-induced amino acids substitutions link the sun’s biological energy from quantum mechanics to biogenesis via light energy changes caused by the earth’s atmosphere, which enable the formation of achiral glycine. From its de novo creation difference in hydrogen energies can be linked to carbon based life via the creation of chiral amino acids and proteins that differentiate all cell types of all individuals of all species. Before I move forward and explain more about physics, here’s a brief review of what others are now claiming. They are still a few years behind the available information on biologically-based cause and effect, but they are sneaking up fact — and not citing my published works as they proceed to make many related claims.

The Gut Microbiome and the Brain

This open access article was published on November 17, 2014 reported on January 22, 2015 as:

You are what you eat: How gut bacteria affect brain health

Excerpt: “In “The Gut Microbiome and the Brain”, Leo Galland, Foundation for Integrated Medicine (New York, NY), presents the most up-to-date understanding of the relationship between the proteins produced by intestinal bacteria and the human central nervous system. The author explores the various mechanisms through which the microbiome can influence the brain: by stimulating and over-stimulating the immune system, producing neurotoxic agents, releasing hormones or neurotransmitters identical to those made by the human body, or through direct neuronal stimulation that sends signals to the brain.”

My comment: The Foundation for Integrated Medicine threw information into the face of the Society for Integrative and Comparative Biology (SICB) members who were left to wonder about biologically based cause and effect that links species from microbes to man — even after their presentations earlier this month linked all crustaceans to all insects.

See: All in the (bigger) family reported January 16, 2015

Excerpt 1) “A flurry of other presentations compared different classes of molecules—respiratory proteins, microRNAs, and the heat shock proteins produced in response to stress—in insects and standard crustaceans.”

Excerpt 2) “In insects, falling levels of so-called juvenile hormone stimulate the transition to adulthood; the analogous hormone in crustaceans is methyl farnesoate, which spurs growth and molting. Juvenile hormone is thought to be specific to insects, whereas methyl farnesoate is inactive in that group. But researchers have learned that production of both hormones depends on the same rate-limiting enzymes. And Jerome Hui of the Chinese University of Hong Kong found that in both insects and crustaceans, the same set of micro RNAs control expression of the genes for those enzymes.”

My comment: Animal models link nutrient-dependent metabolism of food by gut microbes to changes in the microRNA/messenger RNA balance that link the de novo creation of enzymes from  RNA-directed DNA methylation and RNA-mediated amino acid substitutions to cell type differentiation in all cells of all individuals of all species. For examples, see: Nutrient-dependent/pheromone-controlled adaptive evolution: a model. Introduction: “Members of the Society for Integrative and Comparative Biology (SICB) recently organized and held an ecological epigenetics symposium (January, 2013). Clearly, a new generation is familiar with the concept of ecologically driven epigenetic effects, which can be caused by sensory input that effects hormones, which affect behavior.”

In All in the (bigger) family, we read “Insects and crustaceans “are the most divergent organisms on the Earth, and as biologists we’d really like to understand how that came to be,” says Jonathon Stillman, a marine environmental physiologist at San Francisco State University’s environmental research center in Tiburon.”

How could anyone not understand that all organisms are what they eat because what they eat changes the microRNA/messenger RNA balance, which underlies the differences in RNA-mediated amino acids that determine the cell type differences that link morphological and behavioral phenotypes during the development of species from microbes to man?

What’s next:

1) Review: influenza virus in pigs.

2) The pig as a large animal model for characterization of host-pathogen interactions

Excerpt: “…we were able to perform highly controlled experimental infections and to study changes of symptoms, viral titer, and expression of microRNAs/mRNAs as the influenza infection progressed in time…”



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