Nothing new under the sun, except pseudoscientific nonsense

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On the Importance of Being a Methodological Naturalist

Posted on November 5, 2014 by

Excerpt: “…consider the flying spaghetti monster, a deity invented to poke fun at religion. It is ridiculous, but is there any way to prove that it doesn’t exist?”

Conclusion: “If religious believers abandon methodological naturalism, then they are forced to deny not only the laws of physics and the facts biological evolution, but the histories of their own religions.”

My comments: DS Wilson is an evolutionist who seems to believe in ridiculous theories touted by other social scientists. I am a medical laboratory scientist who believes in the laws of physics, the chemistry of protein folding, and the conserved molecular mechanisms that link physics and chemistry to biodiversity. See for comparison Nutrient-dependent/pheromone-controlled adaptive evolution: a model and social interaction and brain Number of Results: 99

Compare accurate representations of biophysical constraints and biologically-based facts in RNA-mediated cell type differentiation and behavior and Epigenetic Shaping of Sociosexual Interactions to DS Wilson’s nonsense.

Start with this belief: The thing that hath been, it is that which shall be; and that which is done is that which shall be done: and there is no new thing under the sun. — Ecclesiastes 1:9

Use that belief about creation to link what is currently known about ecological adaptations that stabilize the Ebola viruses via amino acid substitutions. The highly publicized threat to life as we know it can then be compared to the lack of stability associated with missing amino acid substitutions in undifferentiated cell types of cancers. You can quickly arrive at the end of DS Wilson’s pseudoscientific nonsense about believers who supposedly deny not only the laws of physics and the facts about biophysically-constrained biologically-plausible evolution. Simply put, without the stability of nutrient-dependent amino acid substitutions in species from microbes to man, mutations would lead to more mutations. Accumulated mutations in any organism cannot lead to controlled species diversity.

In the context of  Intelligent viruses and cancers for example, “It appears that nothing about evolution makes sense, unless it is placed back into the context of the light of creation via the de novo creation of olfactory receptor genes. Experience-dependent de novo creation of receptors can be linked from light-induced amino acid substitutions to nutrient-induced RNA-mediated receptor-mediated amino acid substitutions in animals via quaternary and ternary switches. The complexity of these switches, which allow the entry of nutrients into cells, is linked directly to cell type differentiation in health and disease via the conserved molecular mechanisms manifested in the morphological and behavioral phenotypes of species from microbes to man.”

Except for pseudoscientists who cannot grasp the systems complexity of biology, the link from intelligent microbes to human intelligence is clear. It is nutrient-dependent thermodynamic cycles of protein biosynthesis and degradation. These seemingly futile cycles link the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man via their role in cell type differentiation of cells in the human brain. See: Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities.

Creationist believers who know nothing about the difference between pseudoscience and biological facts need only pray that the pseudoscientists stop touting their ridiculous theories before their theories kill us all. The take home message is not only that “…seemingly simple amino acids can exhibit surprisingly complex pharmacology…” It is also that the complexity of pharmacology can be placed into the context of pharmacogenomics and personalized medical care via nutrient-dependent RNA-directed DNA methylation and RNA-mediated events.

RNA-mediated events link the epigenetic landscape to the physical landscape of DNA in organized genomes via conserved molecular mechanisms. The conserved molecular mechanisms link the physics and the chemistry of protein folding to amino acid substitutions that differentiate all cell types in species from microbes to man. Indeed, during the past decade, the atoms to ecosystems links between metabolic networks and genetic networks have become perfectly clear to serious scientists.

See also: Binding thermodynamics of a glutamate transporter homolog “…cation binding and unbinding events are the driving force of the EAAT [excitatory amino acid transporters] transport cycle.” The obvious link from the nutrient-dependent pheromone-controlled cell type differentiation of microbes to man may continue to be ignored by theorists who believe that the invention of their ridiculous theories is all that should be required for others to see the light. But there are Jews, Christians, and Islamic creationists who see the light in the context of Ecclesiastes 1:9. They are not likely to base their beliefs on any invented theories, no matter what self-proclaimed experts tell them about the need to incorporate the laws of physics. Creationist seem to have always intuitively included facts in their beliefs about how biologically-based ecological variation leads to ecological adaptations.

For comparison, experts on evolutionary biology, like DS Wilson, for example, have typically ignored what the creationist / evolutionist Dobzhansky (1973), wrote about amino acid substitutions and cell type differentiation in Nothing in Biology Makes Any Sense Except in the Light of Evolution “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla.”

The history of Abrahamic religions includes the belief that The thing that hath been, it is that which shall be; and that which is done is that which shall be done: and there is no new thing under the sun. The history of social science appears to include belief in theories that were invented via the use of definitions to make it appear that mutations and natural selection somehow led to the evolution of biodiversity, which has since been linked directly from nutrient-uptake to variations in single nutrient-dependent amino acid substitutions.

DS Wilson’s claims that religious believers are forced to deny anything about physics, biology, and creation can be compared to what evolutionary theorists and evolutionary theists prefer to believe. They appear to believe in simple-minded assumptions because they were taught to believe the assumptions were based on biological facts that included what was known about physics and chemistry.

[W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et al. did was invent…. The anglophone tradition was taught. I was taught, and so were my contemporaries, and so were the younger scientists. Evolution was defined as “changes in gene frequencies in natural populations.” The accumulation of genetic mutations was touted to be enough to change one species to another…. No, it wasn’t dishonesty. I think it was wish fulfillment and social momentum. Assumptions, made but not verified, were taught as fact.

Experts like Susan M. Rosenberg and Christine Queitsch are among the serious scientists who continue Combating Evolution to Fight Disease at the same time that pseudoscientists like DS Wilson continue their attempts to get others to ignore Abrahamic faith in the light of creation. Claims that pseudoscientific theories incorporate the laws of physics and the facts about biological evolution can now be placed into the context of a model that integrates what is currently known about epigenetic links light-induced amino acid substitutions to the de novo creation of stabilized new cell types via nutrient-dependent amino acid substitutions and the pheromone-controlled physiology of reproduction.

Nutrient-dependent pheromone-controlled ecological adaptations: from atoms to ecosystems

Abstract: “This atoms to ecosystems model of ecological adaptations links nutrient-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA / messenger RNA balance and chromosomal rearrangements. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experience-dependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent pheromone-controlled ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity in species from microbes to man. Species diversity is a biologically-based nutrient-dependent morphological fact and species-specific pheromones control the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection of nutrients cause the behaviors that enable ecological adaptations. Species diversity is ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. This is known: Olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man during their development.”

See also: Genetically Engineering Almost Anything.  Try to place the claims about Cas9-based gene drives outside the facts about physics and chemistry. The facts can be viewed in the light of conserved molecular mechanisms that link nutrient-dependent RNA-mediated cell type differentiation via amino acid substitutions from the epigenetic landscape the the physical landscape of DNA in the organized genomes. If the organized genomes of all species that were ever created were oraganized in the context of the first light of creation, the only thing new under the sun appears to be the pseudoscience of ridiculous theories.

Summary:

1) In my model, RNA-mediated events in mammals incorporate what is known from “… intensive and extensive analyses of the effects of various factors, such as neurotransmitters, gonadal steroids, energy balance, and pheromones, on the GnRH pulse generator, and will thus increase our understanding of the central mechanisms that control reproduction.

2) Evolutionary events that include the laws of physics, the chemistry of protein folding, or the conserved molecular mechanisms of ecological speciation that link microbes to man have never been detailed.

3) Minimally, however, it appears that experts like DS Wilson are beginning to realize that they must try to incorporate the laws of physics into their ridiculous theories about biodiversity. Without the laws of physics, the light that shines on nutrient-dependent pheromone-controlled ecological adaptations in the context of Dobzhansky’s creationist beliefs has not penetrated the minds of pseudoscientists who were taught to believe in ridiculous theories about mutations.

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