Lost archives and cell type differentiation information

The life cycle of an mRNA in a eukaryotic cell RNA is transcribed in the nucleus processing, it is transported to the cytoplasm and translated by the ribosome. Finally the mRNA is degraded
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A Sexologist and his two Archives: Erwin J. Haeberle

Excerpt: I did read the great study Die Prostitution (1912) by Iwan Bloch, one of the great pioneers of sexology.

My comment: See also by Iwan Bloch: Odoratus Sexualis: A Scientific And Literary Study Of Sexual Scents And Erotic Perfumes

“It is important to remember that the animal perceives erotic odors in a manner analogous to his perception of food odors” (p. 31).

Most researchers who study human sexuality have failed to learn that one pathway links food odors to hormones and behavior. It also links human pheromones to hormones and behavior.

In other animals, the nutrient-dependent pheromone-controlled pathway is linked from the epigenetic effects of food odors and pheromones to the differentiation of all cell types in all individuals of all species. Conserved molecular mechanisms link the biophysically constrained chemistry of RNA-mediated protein folding to sex differences in cell types and to the differentiation of all other cell types in all tissues of all organs and all organisms of all mammals.

The gonadotropin releasing hormone neuronal system links the epigenetic landscape to the physical landscape of DNA in the organized genomes of all vertebrates. Simply put, Feedback loops link odor and pheromone signaling with reproduction via epigenetic effects on GnRH.

Nobel Laureate Linda Buck co-authored of the article on feedback loops. This claim was made: “Indications that GnRH peptide plays an important role in the control of sexual behaviors suggest that pheromone effects on these behaviors might also involve GnRH neurons” (p 683).

The importance of GnRH to cell type differentiation and to behavior cannot be overstated. Noradrenergic, dopaminergic, serotoninergic, and opiotergic pathways; inhibitory neurotransmitters (e.g., gamma aminobutyric acid) and excitatory amino acids (e.g., glutamic and aspartic acids); and other brain peptides including pineal secretions (melatonin) and corticotrophin releasing hormone, and the complex interactions among them are subtle but functional species-specific influences on the electrochemical transmission of neuronal signals that the hypothalamus translates to the chemical signal GnRH.

The link from nutrient-dependent RNA-directed DNA methylation and RNA-mediated amino acid substitutions that differentiate the cell types of different species is an important link to the understanding of the difference between health and mutations linked to physiopathology. Why is Erwin J. Haeberle’s “Archive for Sexology” the only primary source for free and accurate information on the biological basis of cell type differentiation? What will happen when he is no longer able to bear the costs of maintaining that source?

Here’s an example: In 2011, Simon LeVay wrote (Gay, Straight, and the Reason Why: The Science of Sexual Orientation)

“This model is attractive in that it solves the “binding problem” of sexual attraction. By that I mean the problem of why all the different features of men or women (visual appearance and feel of face, body, and genitals; voice quality, smell; personality and behavior, etc.) attract people as a more or less coherent package representing one sex, rather than as an arbitrary collage of male and female characteristics. If all these characteristics come to be attractive because they were experienced in association with a male- or female-specific pheromone, then they will naturally go together even in the absence of complex genetically coded instructions.”

Still, even in fruit flies, other sensory input besides pheromones — acoustic, tactile, and visual stimuli — play a role in sexual attraction, and sex specific responses to these stimuli appear to be innate rather than learned by association [36.]. We simply don’t know where the boundary between prespecified attraction and learned association lie in our own species, nor do we have compelling evidence for the primacy of one sense over another” (p. 210)

Erwin J. Haeberle’s “Archive for Sexology” is the only source for a free author’s copy of the award-winning journal article and book chapter that contains the model LeVay claims solves the “binding problem” of sexual attraction. See: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences. The model is based on the first publication to detail the molecular epigenetics of RNA-mediated cell type differentiation in yeasts, flies, and all other animal species. Obviously, there is overwhelming compelling evidence for the primacy of olfaction over all other sensory input. Humans Can Discriminate More than 1 Trillion Olfactory Stimuli. See also:  “It’s time to give our sense of smell the recognition it deserves,” said Vosshall. But don’t expect LeVay to do that.

Instead, see Erwin J. Haeberle’s “Archive for Sexology.” It is also source for a free authors’ copy of a 1996 Hormones and Behavior review that linked food odors and pheromones: From Fertilization to Adult Sexual Behavior. The model was extended to insects in 2000 and to the life history transitions of the honeybee model organism in 2005 before it’s inclusion in Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors and in Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

The honeybee already serves as a model organism for studying human immunity, disease resistance, allergic reaction, circadian rhythms, antibiotic resistance, the development of the brain and behavior, mental health, longevity, diseases of the X chromosome, learning and memory, as well as conditioned responses to sensory stimuli (Kohl, 2012).

An interview article that links viruses from the origin of life to cell type differentiation is available here. Luis P. Villarreal: We Need a Nonlinear Language for Life.

A review of the 1999 book that linked the 1996 model that solves the binding problem of sexual attraction from ecological variation to ecological adaptations in species from microbes to man is here: Review: NATURE Substantial excerpt from a review published in NATURE, March 2, 2000. By MICHAEL A. GOLDMAN

If Erwin J. Haeberle’s “Archive for Sexology” cannot become financially secure, future generations may have no source of accurate information about any model of biologically-based top-down causation that links the epigenetic landscape to the physical landscape of DNA in species from microbes to man via the original thoughts of people like Iwan Bloch and Havelock Ellis. The loss of the information source for a century’s worth of facts will benefit social scientists who support the evolution industry and theoretical physicists who support the “big bang” cosmology industry. Simply put, loss of Erwin J. Haeberle’s “Archive for Sexology”  will mean a loss of a source for the accurate dissemination of information about cell type differentiation at a time when serious scientists are Combating Evolution to Fight Disease and at a time when there has been no noticeable progress from sex researchers during the past two decades.

See: Explaining Same-Sex Sexual Behavior: The Stagnation of the Genetic and Evolutionary Research Programs.

Today’s sex researchers still cannot explain how sex differences in cell type arose. With the loss of Erwin J. Haeberle’s “Archive for Sexology” we may be forever told about the magic of mutations and evolution.

Will you be content to leave what is currently known about the physics, chemistry, and conserved molecular mechanisms of cell type differentiation and every other aspect of nutrient-dependent pheromone-controlled physiology of reproduction in the hands of theorists? If not, you may want to donate to Erwin J. Haeberle’s “Archive for Sexology

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Archive for Sexology Founded 1994 by Erwin J. Haeberle

My Archive offers freely accessible scientific information on sexual health in 15 languages.
http://www.sexarchive.info/

This includes a.o. large online libraries in 4 languages: English, Spanish, German, and Hungarian.

My online curriculum “Sexual Health“ of 6 courses (6 semesters) is available in 7 languages: English, Spanish, Portuguese, Chinese (both simplified and traditional), Russian, Czech, and Hungarian.
Some of the courses are also available in other languages.

In addition, I offer 23 shorter and longer videos on YouTube dealing with sexual health. So far, they have registered 380 000 visits.

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