Human pheromones: RNA-mediated theory killers

social interaction and brain
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A Fear of Pheromones

Excerpt:

WHAT are we going to do if it turns out that we have pheromones? What on earth would we be doing with such things? With the richness of speech, and all our new devices for communication, why would we want to release odors into the air to convey information about anything?”

My comment: It became clearer today that even by again linking microbes to humans, as we did in our 1996 review of RNA-mediated cell type differentiation, others will not accept any experimental evidence that links conserved molecular mechanisms of cell type differentiation from atoms to ecosystems.

See for example:

A Cellular System for Spatial Signal Decoding in Chemical Gradients was reported as  A multitool for cells: Understanding the sense of smell in cells.

Excerpt 1)

The ETH researchers have now provided this explanation and described in detail for the first time how cells can locate a scent gradient. This work lays an important foundation stone for further studies on spatial signal perception by cells – both in yeast and in humans.

The researchers linked atoms to ecosystems in the context of a quote from 1980 On Smell

I should think we might fairly gauge the future of biological science, centuries ahead by estimating the time it will take to reach a complete comprehensive understanding of odor. It may not seem a profound enough problem to dominate all the life sciences, but it contains, piece by piece, all the mysteries (p. 732).

— Lewis Thomas as cited in The Scent of Eros: Mysteries of Odor in Human Sexuality

After they solved the mysteries in the context of sensing, secreting, and signaling in species from microbes to humans, the first author of the report supposedly claimed that:

Excerpt 2)

…currently no direct medical applications are envisaged: “In the distant future, this work might well benefit the general public. At the moment, however, it primarily represents an important advance for fundamental research.

My comment: The research already links sensing, secreting, and signaling from ecological variation to ecological adaptation in all living genera. Perhaps it is time to compare the mysteries of odor that have been solved to any unsolved mysteries about systems for chemical signaling that extend across spatial gradients of coding and uncoding that is required for the survival of every cell type in every individual of every species from microbes to humans.

For example:

Excerpt 3)

Yeast cells have a very fine, adjustable multitool that recognises chemical signals, processes them accordingly, and initiates the correct response – growth towards the source of the signal. Yeast cells are therefore able to smell the location of potential sexual partners in their surroundings, so that they can grow towards them.

My comment: Until recently, the molecular mechanisms of the adjustable multitool were unknown. Nearly all evolutionary theorists attributed the fine tuning of this adjustable multitool to mutations, which somehow ensured survival of species that reproduce asexually and sexually via natural selection for something and evolution. Recently, however, some evolutionary theorists have accepted the fact that natural selection cannot explain any aspect of cell type differentiation that must be selected to repair DNA and ensure that the lack of nutrients, toxic substances, or too much of something good to eat does not cause cell death. No theorist has yet claimed to know anything about the GnRH decapeptide hormone that links the nutrient-dependent pheromone-controlled reproduction of yeasts to mammals. Instead they ignore past publications like this one.

Neuropeptides and Psychiatric Disorders (Progress in Psychiatry)

See the chapter: Gonadotropin releasing hormone and human sexual behavior

Excerpt ( p. 61)

The universality of the GnRH-induced behavioral response in the nonhuman species (from lizard to monkey) and the endocrine-pituitary actions of GnRH in pituitary secretion of LH and FSH, couples with the possible relationship between human sexual behavior deficits and gonadotropin dysfunction, provided good justification to proceed with further investigation into the behavioral effects of GnRH on human sexual behavior.

The 1991 book editor is Charles Nemeroff, who is also co-author of Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.

Reported as: Epigenetic Aging Accelerated by Lifetime Stress

Conclusion: 

Measuring the epigenetic age in peripheral blood cells may be a possibility to identify chronically stressed individuals at high risk for cardiovascular diseases or dementia and to initiate timely prevention programs.

My comment: Kerry J. Ressler is co-author of the article on “Lifetime stress” and also a co-author of Parental olfactory experience influences behavior and neural structure in subsequent generations and also co-author of Epigenetic mechanisms underlying learning and the inheritance of learned behaviors and co-author of Impact of Stress on the Brain: Pathology, Treatment and Prevention

I do not know how Kerry Ressler or Charles Nemeroff could have missed the connections from the yeasts to humans, since the the decapeptide pheromone in yeast is similar enough to mammalian GnRH to elicit an LH surge in a mammal, the rat. If nutrient-dependent pheromone-controlled physiology of reproduction links yeasts to rats, questions arise about how diet influences humans.

For example: How Does Diet Influence Immunity

Does the diet of humans link physics and chemistry to RNA-mediated cell type differentiation in all living genera?

See also: Physics sheds light on stem cell-derived organoid growth, brain development

Excerpt:

Stem cells have very unique behaviors and responses to specific concentrations of many molecular factors, meaning that it is important to understand the complex dynamics of nutrient signaling, diffusion, and metabolism in 3D tissues.

My comment: The only way to look at this in the light, is to link the light from atoms to ecosystems in the context of what is known to serious scientists about biologically based cause and effect. Looking at the complexity of equations is like bird-watching or butterfly collecting, which are ways that evolutionary theorists and human ethologists have wasted the time of neuroscientists. The links from stem cells to brain development are different in the context of his typical banter. They obviously link nutrient-dependent RNA-mediated amino acid substitutions to cell type differentiation in the human brain via a single amino acid substitution during life history transitions.

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults

That fact is an evolutionary theory killer. It links the honeybee model organism of learning and memory during the cell type differentiation of all colony members to life history transitions via the molecular mechanisms we detailed in the context of our 1996 review, which were extended to insects and to the life history transitions of honeybees before I extended them to humans in a 2013 review and Polese et al (2015) linked all invertebrates to all vertebrates via olfaction in octopuses.

See: Role of olfaction in Octopus vulgaris reproduction — p. 61

Excerpt: 

Future work on O. vulgaris olfaction must also consider how animals acquire the odours detected by the olfactory organ and what kind of odour the olfactory organ perceives. The OL acting as control centre may be target organ for metabolic hormones such as leptin like and insulin like peptides, and olfactory organ could exert regulatory action on the OL via epigenetic effects of nutrients and pheromones on gene expression (Kohl, 2013; Elekonich and Robinson, 2000).

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