Conserved molecular mechanisms

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In RNA-mediated events: chromosomal rearrangements and genomic rearrangements, I wrote:

John Hewitt is the only science journalist I know who may have the knowledge required to link bio-physically constrained epigenetically-effected cell type differentiation via Luca Turin’s Molecular Vibration-Sensing Component in Human Olfaction from the de novo creation of olfactory receptor genes to the differentiation of cell types in species from microbes to man via conserved molecular mechanisms.

Origin of the Eukaryotic cell: Part I – How to train your endosymbiont

by John Hewitt Dec 04, 2014

Excerpt 1)The origin and evolution of eukaryotes” is a tale that has yet to be told. At this point in time, it exists only as the title of a fascinating new compendium that has just been produced by the Cold Spring Harbor Press.

My comment: In part 1 of his review of this compendium, John Hewitt draws from his background in physics and neuroscience and prior writings in the fields of neuroscience, cell biology, and general technology. Who else could include a link to his own writings on the “hydrogen hypothesis” to help place The energetic origins of life into a perspective outside the context of definitions and assumptions? Most science journalists simply accepted the use of de Vries definition of ‘mutation’ and assumption made by evolutionary theorists about the role that mutations must play in the evolution of biodiversity. Instead, he wrote: “The flow of electrons through proteins, and the membranes which house them, continues to be one of the most exciting areas both in the origins of life, and in the creatures later evolved.” Now, we begin to see how what is currently known about physics, chemistry, and the conserved molecular mechanisms of cell type differentiation attest to links between ecological variation and ecological adaptations that do not require anyone to include the pseudoscientific nonsense of ridiculous gene-centric theories.

Excerpt 2) One good example of how to quickly get confused when favoring a gene-centric approach at the expense of paleontologic or structural organelle-level analysis is with ribosomes. While horizontal, lateral and verticle gene flow among bacteria, archaea, and eukaryotes are constant confusers across species, the ribosomal RNA and riboproteins that exist in several unique cell-trafficking or inheritance scenarious in the organelles of single cell can be even more confounding.

My comment: Watch as he takes us from focus on DNA and the gene-centric approach used to invent and promote neo-Darwinism to an understanding of biologically-based cause and effect that includes what is known about physical and chemical constraints on protein folding.

Excerpt 1) “A few key features of how cilia or flagella are built in bacteria, archaea and eukarytoes are probably worth mentioning here. The bacterial flagellum evolved not only to give creationists something to get worked up about, but also to give the origin of life sleuths a fascinating puzzle.”

My comment: The issue for creationists is much more to get worked up about than just the flagella. Unlike evolutionary theorists, the creationists have not been duped into thinking that mutations can cause cell type differentiation in gram positive and gram negative bacteria or that mutations cause antibiotic resistance. If they have any interest in understanding creation, they have already found out about nutrient-dependent RNA-directed DNA methylation and RNA-mediated events that link quantum physics to the chemistry of protein folding and quantum biology of cell type differentiation via amino acid substitutions in species from microbes to man.

For example, “Penicillin and its variants also set in motion a toxic malfunctioning of the cell’s wall-building machinery, which dooms the cell to a futile cycle of building and then immediately destroying that wall.” Seemingly futile cycles of nutrient-dependent protein biosynthesis and degradation enable the construction of the cell wall in bacteria and the characteristics of the cell wall are conserved across species by their pheromone-controlled reproduction. Thus, knowing how penecillin and its variants cause malfunctions of the cell wall-building machinery attests to how cell wall construction typically occurs. The role of nutrient-dependent amino acid substitutions becomes clearer because they are obviously required for the protein folding that enables duplication of genes in cell types and differences in cell types that cannot be attributed to mutations that perturb protein folding. Perturbed protein folding manifested in the effects of penicillin and its variants clearly doom the cell to its death. It does not mutate into another species to escape its fate, contrary to what evolutionary theorists might like you to believe.

As John Hewitt continues with his review of  “The origin and evolution of eukaryotes” we can expect to see details about the chapter The Persistent Contributions of RNA to Eukaryotic Gen(om)e Architecture and Cellular Function as Hewitt takes us further away from theory and closer towards explanations of biologically-based cause and effect that include what is known about physics, chemistry, cell biology and about how ecological variation leads to ecological adaptation in species from microbes to man.

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