Neuronal Plasticity

Understanding cell type differentiation

Genetic code

The Wisdom of the Fly Crowds by Ed Yong Excerpt: “This is a landmark study of collective behaviour,” says Iain Couzin… “Never before has it been possible to unweave the intricate coding of social behaviour during collective decision-making.” When it…
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Ecological adaptations reported as evolution in insects and mammals

rp_poster-from-jesse.jpg

Evolution of mosquito preference for humans linked to an odorant receptor Excerpt: “Our results also provide insight into the molecular basis of behavioural evolution.” See their diagram in Extended Data Figure 3: Amino acid differences of major Or4 protein alleles….
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RNA-mediated cell type differentiation and behavior

human-evolution

Neuroscience Meeting Planner Now Available The Preliminary Program and Neuroscience Meeting Planner for Neuroscience 2014 are available. At the 2012 Meeting I learned that the microRNA/messenger RNA balance had emerged during the past decade to be the most likely regulator…
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Metabolism, fixation, health or neurodegerative disorder

neuronal-plasticity

“Shown is the location of the conserved regions encoding for the N-terminal chromo domain and the C-terminal MYST functional domain. An arrow denotes the position site of amino acid substitution E431Q.” Microarray Analysis Uncovers a Role for Tip60 in Nervous…
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Genotype, observed phenotype, and distinctly disordered behaviors

social interaction and brain

Schizophrenia not a single disease but multiple genetically distinct disorders September 15, 2014 By Jim Dryden News article excerpt: “Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert…
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Epigenetic modulation of odor response

neuronal-plasticity

Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala Abstract excerpt: “These results demonstrate an epigenetic proximate mechanism underlying the extended phenotype in the Rattus novergicus – Toxoplasma gondii association.” Reported as: Parasites…
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An evolving view eliminates evolutionary theory

social interaction and brain

An evolving view of epigenetic complexity in the brain Abstract (with my emphasis): Recent scientific advances have revolutionized our understanding of classical epigenetic mechanisms and the broader landscape of molecular interactions and cellular functions that are inextricably linked to these…
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From odors to autism spectrum disorder

Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder clearly links the de novo creation of olfactory receptor gene OR2L13, from decreased nutrient-dependent DNA methylation to sensory processing in ASD’s. A series of published works I posted yesterday in Ecological variation…
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BioAnthropology News: it’s evolution; no epigenetics allowed

neuronal-plasticity

“Human Evolution: Early Human Diets” webcast Excerpt: What was on the dinner plate for early humans a million years ago? My comment: A million years ago? I think 30, 000 years is a stretch given the speed at which ecological…
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